Responses of sagittally aligned Purkinje cells during perturbed locomotion: relation of climbing fiber activation to simple spike modulation.
Responses of sagittally aligned Purkinje cells during perturbed locomotion: relation of climbing fiber activation to simple spike modulation.
复制标题
矢状排列的浦肯野细胞在扰动运动过程中的反应：攀爬纤维激活与简单尖峰调制的关系。
DOI：
10.1152/jn.1992.68.5.1820
复制
发表时间：
1992
影响因子：
2.5
通讯作者：
Bloedel,JR
中科院分区：
文献类型：
--
作者：
Lou,JS;Bloedel,JR
1.这些实验的目的是测试的假设，矢状排列的浦肯野细胞的同步激活生理相关的刺激与相同的神经元的简单的尖峰反应的增加。2.这一假设进行了测试，使用扰动的运动范式在去大脑的arteroting雪貂。同时记录3-5个矢状排列的浦肯野细胞对摆动期前肢间歇性扰动的反应。介绍了一种数据分析，真实的时间突触后反应（RTPR），它允许量化的浦肯野细胞的简单的尖峰反应的方式，可以与他们的复杂的尖峰反应在一个试验的基础上。3.这些数据支持上述假设，说明了浦肯野细胞群体中的组合简单棘波反应的幅度与其攀爬纤维输入被同步激活的程度相关。这些研究结果与增益变化率的分析支持的观点，同步攀爬纤维输入可能是负责调解这种增加的反应。4.更一般地说，这些数据表明，任务和/或行为依赖性激活矢状带的攀爬纤维输入可以提供一种机制，从而离散群体的浦肯野细胞的反应性可以选择性地调节，指定组的神经元，将最显着调制苔藓纤维输入激活相同的条件。
1. The purpose of these experiments is to test the hypothesis that the synchronous activation of sagittally aligned Purkinje cells by a physiologically relevant stimulus is associated with an increase in the simple spike responses of the same neurons. 2. This hypothesis was tested using a perturbed locomotion paradigm in decerebrate locomoting ferrets. The responses of 3-5 sagittally aligned Purkinje cells were recorded simultaneously in response to the intermittent perturbation of the forelimb during swing phase. A data analysis is introduced, the real time postsynaptic response (RTPR), that permits the quantification of the simple spike responses of Purkinje cells in a manner that can be related to their complex spike responses on a trial-by-trial basis. 3. The data support the above hypothesis by illustrating that the amplitude of the combined simple spike responses across the population of Purkinje cells is correlated with the extent to which their climbing fiber inputs are synchronously activated. These findings together with an analysis of the gain-change ratio support the view that the synchronous climbing fiber input may be responsible for mediating this increased responsiveness. 4. More generally, the data suggest that the task- and/or behaviorally dependent activation of sagittal strips of climbing fiber inputs may provide a mechanism whereby the responsiveness of discrete populations of Purkinje cells can be selectively regulated, specifying the groups of neurons that will be most dramatically modulated by mossy fiber inputs activated by the same conditions.