Amphidinins C-F, amphidinolide Q analogues from marine dinoflagellate Amphidinium sp.
Amphidinins C-F, amphidinolide Q analogues from marine dinoflagellate Amphidinium sp.
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DOI：
10.1021/ol502685z
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发表时间：
2014-10
期刊：
影响因子：
5.2
通讯作者：
T. Kubota;T. Iwai;Kanae Sakai;T. Gonoi;J. Kobayashi
中科院分区：
文献类型：
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作者：
T. Kubota;T. Iwai;Kanae Sakai;T. Gonoi;J. Kobayashi
从共生双鞭毛藻Amphidinium sp.的培养液中分离到4个新的多酮类化合物amphidinins C-F（1-4）。对它们的光谱数据分析表明，amphidinins C-F（1-4）是amphidinolide Q(5)的4,5-seco类似物。通过j基构型分析、改进的Mosher法和化学衍生法对新化合物的绝对构型进行了分析。两萜苷D(2)和F(4)是最早与两萜内酯相关的苷类。Amphidinins C-F（1-4）对细菌和/或真菌具有抗菌活性。
Four new polyketides, amphidinins C-F (1-4), have been isolated from the culture broth of symbiotic dinoflagellate Amphidinium sp. The analysis of their spectral data revealed that amphidinins C-F (1-4) were 4,5-seco-analogues of amphidinolide Q (5). The absolute configurations of the new compounds were elucidated by the combination of J-based configuration analysis, modified Mosher's method, and chemical derivatization. Amphidinins D (2) and F (4) are the first glycosides related to amphidinolides. Amphidinins C-F (1-4) showed antimicrobial activity against bacteria and/or fungi.