Clinicopathological features of and risk factors for multiple primary melanomas
Clinicopathological features of and risk factors for multiple primary melanomas
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DOI：
10.1001/jama.294.13.1647
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发表时间：
2005-10-05
影响因子：
120.7
通讯作者：
Coit, DG
中科院分区：
文献类型：
--
作者：
Ferrone, CR;Ben Porat, L;Coit, DG
背景在大量的回顾性研究中，多发性原发性黑色素瘤的发病率为1.3%-8.0%;然而，某些危险因素的影响尚不清楚。目的从前瞻性、单机构、多学科数据库中确定多发性原发性黑色素瘤（MPM）的发病率，并描述这些患者的临床和病理特征以及特定的危险因素。Memorial前瞻性维护数据库的设计和设置回顾1996年1月1日至2002年12月31日，共有4484例原发性黑色素瘤患者被诊断为MPM。主要结果测量MPM的发病率和危险因素。结果385例患者（8.6%）有2个或更多的原发性黑色素瘤，平均每个MPM患者有2.3个黑色素瘤。78%有2个原发性黑色素瘤。对于74%的患者，最初的黑色素瘤是最厚的肿瘤。59%的患者在1年内出现了第二个原发性肿瘤。21%的MPM患者有黑色素瘤阳性家族史，而只有12%的单一原发性黑色素瘤（SPM）患者有黑色素瘤阳性家族史（P
Context The,incidence of multiple primary melanomas ranges from 1.3% to 8.0% in large retrospective reviews; however, the impact of certain risk factors is not understood.Objectives To determine the incidence of multiple primary melanomas (MPM) from a prospective, single-institution, multidisciplinary database, and to describe the clinical and pathological characteristics and risk factors specific to these patients.Design and Setting Review of a prospectively maintained database at Memorial Sloan-Kettering Cancer Center in New York, NY.Patients A total of 4484 patients diagnosed with a first primary melanoma between January 1, 1996, and December 31, 2002.Main Outcome Measures Incidence of and risk factors for MPM.Results Three hundred eighty-five patients (8.6%) had 2 or more primary melanomas, with an average of 2.3 melanomas per MPM patient. Seventy-eight percent had 2 primary melanomas. For 74% of patients, the initial melanoma was the thickest tumor. Fifty-nine percent presented with their second primary tumor within 1 year. Twenty-one percent of MPM patients had a positive family history of melanoma compared with only 12% of patients with a single primary melanoma (SPM) (P