Effects of indomethacin on myogenic contractile activation and responses to changes in O2 and CO2 in isolated feline cerebral arteries.
Effects of indomethacin on myogenic contractile activation and responses to changes in O2 and CO2 in isolated feline cerebral arteries.
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吲哚美辛对离体猫脑动脉中肌原性收缩激活以及对 O2 和 CO2 变化的反应的影响。
DOI：
10.1038/jcbfm.1992.118
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Madden,JA
中科院分区：
文献类型：
--
作者：
Norins,NA;Wendelberger,K;Hoffman,RG;Keller,PA;Madden,JA
We used an isolated, pressurized, and perfused feline middle cerebral artery preparation to measure how changes in intraluminal pressure and alterations in O2and CO2affect vessel diameter and myogenic contractile activation before and after treatment with indomethacin (IND). Vessel diameters were measured over the pressure range 60–140 mm Hg. The arteries were then exposed to low O2(50 torr) and/or high CO2(65 torr) and diameters remeasured over the same range. Under control conditions, the arteries exhibited myogenic contractile activation. Exposure to low O2, high CO2, or a mixture of low O2/high CO2, increased vessel diameter but did not change the vessels' myogenic contractile responsiveness to changes in pressure. Arteries exposed to IND decreased in diameter but retained myogenic contractile activity. In the presence of IND, vessels dilated to both low O2and a mixture of low O2/high CO2, but did not dilate to high CO2alone. Under all conditions, vessels retained myogenic contractile activity. Results obtained under control conditions and low O2confirm those of others using similar systems. Myogenic contractile activity in the presence of high CO2or a mixture of low O2/high CO2has not been previously reported. The dilation to low O2but not to high CO2in the presence of IND suggests that this drug's effects in cerebral arteries are not limited solely to inhibition of prostaglandin synthesis.
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作者：
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通讯作者：
T. L. Yaksh;Robert L. Plant;T. Rudy
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影响因子：
2.9
作者：
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作者：
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DOI：
10.1098/rstb.1985.0037
发表时间：
1985-01-01
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
FIELDS, HL;HEINRICHER, MM
通讯作者：
HEINRICHER, MM
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影响因子：
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作者：
J. Dostrovsky;Y. Shah;B. Gray
通讯作者：
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