Noninvasive electrocardiographic imaging of arrhythmogenic substrates in humans.
Noninvasive electrocardiographic imaging of arrhythmogenic substrates in humans.
复制标题
DOI：
10.1161/circresaha.112.279315
复制
发表时间：
2013-03-01
影响因子：
20.1
通讯作者：
Rudy Y
中科院分区：
文献类型：
--
作者：
Rudy Y
心脏兴奋是由电激活源(膜去极化)和心脏组织所呈现的负荷之间的相互作用决定的。这种关系在病理上被重塑过程改变，重塑过程往往产生有利于心律失常发展的底物。大多数关于心律失常机制和致心律失常底物的研究都是在动物模型中进行的，这些动物模型可能在重要方面与它们所代表的人类病理学有所不同。心电成像(ECGI)是一种非侵入性的方法，可以在“真实世界”的条件下绘制人类心脏的电活动图。本文综述了ECGI对与人类临床心律失常相关的致心律失常底物的研究结果。例如：心力衰竭、心肌梗死疤痕、房颤和室性复极异常。
Cardiac excitation is determined by interactions between the source of electrical activation (membrane depolarization) and the load that cardiac tissue presents. This relationship is altered in pathology by remodeling processes that often create a substrate favoring the development of cardiac arrhythmias. Most studies of arrhythmia mechanisms and arrhythmogenic substrates have been conducted in animal models, which may differ in important ways from the human pathologies they are designed to represent. Electrocardiographic imaging (ECGI) is a noninvasive method for mapping the electrical activity of the heart in humans, under “real world” conditions. This review summarizes results from ECGI studies of arrhythmogenic substrates associated with human clinical arrhythmias. Examples include: heart failure, myocardial infarction scar, atrial fibrillation and abnormal ventricular repolarization.