Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance Imaging of vascular targets
Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance Imaging of vascular targets
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DOI：
10.1021/ja801482d
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发表时间：
2008-07-23
影响因子：
15
通讯作者：
Lanza, Gregory M.
中科院分区：
文献类型：
--
作者：
Pan, Dipanjan;Caruthers, Shelton D.;Lanza, Gregory M.
虽然钆一直是MR顺磁造影剂的主要顺磁金属，但最近这种镧系元素与肾源性系统性纤维化（一种无法治愈的疾病）的关联，重新引起了人们对MR分子成像替代金属的兴趣。我们已经开发了一种自组装的锰（III）标记的纳米生物（1），一种环形MR治疗诊断纳米颗粒。在这份报告中，Mn（III）nanobialys的特点是作为MR分子成像剂有针对性地检测纤维蛋白，血栓的主要生化特征。nanobialys以大于98%的效率掺入化疗化合物并在无限下沉溶解后保留超过80%的这些药物的互补能力，指向这种平台技术的治疗诊断潜力。
Although gadolinium has been the dominant paramagnetic metal for MR paramagnetic contrast agents, the recent association of this lanthanice with nephrogenic systemic fibrosis, an untreatable disease, has spawned renewed interest in alternative metals for MR molecular imaging. We have developed a self-assembled, manganese(III)-labeled nanobialys (1), a toroidal-shaped MR theranostic nanoparticle. In this report, Mn(III) nanobialys are characterized as MR molecular imaging agents for targeted detection of fibrin, a major biochemical feature of thrombus. A complementary ability of nanobialys to incorporate chemotherapeutic compounds with greater than 98% efficiency and to retain more than 80% of these drugs after infinite sink dissolution, point to the theranostic potential of this platform technology.