Cellular and molecular mechanisms of breast cancer susceptibility.
Cellular and molecular mechanisms of breast cancer susceptibility.
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DOI：
10.1042/cs20211158
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发表时间：
2022-07
期刊：
影响因子：
6
通讯作者：
Sundus F. Shalabi;Mark A. LaBarge
中科院分区：
文献类型：
--
作者：
Sundus F. Shalabi;Mark A. LaBarge
有太多公认的乳腺癌危险因素，但对其生物学机制知之甚少或推测不清。预防方案的缺乏突显了了解癌症易感性的机制基础和寻找预防乳腺癌的新靶点的重要性。到目前为止，我们主要通过应用流行病学和评估大规模人类队列的结果来了解风险和癌症易感性。相对风险被分配给各种人类行为和条件，但总的来说，这种关联很弱，对机制了解很少。到目前为止，衰老是BC的最大风险因素，人们普遍认为有几种特定形式的遗传风险会导致BC。我们建议，将重点放在这些形式的风险背后的生物学上，将阐明BC易感性的生物学机制。
There is a plethora of recognized risk factors for breast cancer (BC) with poorly understood or speculative biological mechanisms. The lack of prevention options highlights the importance of understanding the mechanistic basis of cancer susceptibility and finding new targets for breast cancer prevention. Until now, we have understood risk and cancer susceptibility primarily through the application of epidemiology and assessing outcomes in large human cohorts. Relative risks are assigned to various human behaviors and conditions, but in general the associations are weak and there is little understanding of mechanism. Aging is by far the greatest risk factor for BC, and there are specific forms of inherited genetic risk that are well-understood to cause BC. We propose that bringing focus to the biology underlying these forms of risk will illuminate biological mechanisms of BC susceptibility.