Single‐Irradiation Simultaneous Dual‐Modal Bioimaging Using Nanostructure Scintillators as Single Contrast Agent
Single‐Irradiation Simultaneous Dual‐Modal Bioimaging Using Nanostructure Scintillators as Single Contrast Agent
复制标题
使用纳米结构闪烁体作为单一造影剂的单辐射同时双模式生物成像
DOI：
10.1002/adhm.201801324
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发表时间：
2019
影响因子：
10
通讯作者：
Ning Gu
中科院分区：
文献类型：
--
作者：
Qiang Ju;Shouhua Luo;Chunxiao Chen;Zhenlan Fang;Shengkai Gao;Gong Chen;Xueyuan Chen;Ning Gu
对临床诊断工具不断增长的需求导致了对多模式生物成像系统的广泛研究。与单模式检测不同，多模式成像不仅可以提供功能和结构信息，还可以解决灵敏度、深度和成本问题。尽管付出了巨大的努力，但传统的获得多模式成像的循序渐进的过程对其实际应用构成了严重的限制。在这项工作中，X射线作为高穿透辐射被提出作为单一照射源，而镧系纳米结构闪烁体被用作单一对比剂来衰减和转换X射线，同时实现计算机层析成像(CT)和光学双模成像。也就是说，CT和光学双模成像是通过单次辐射结合单次造影剂同时产生的。在小鼠模型中，靶向肿瘤的功能和结构信息可以清楚地提供，具有大的穿透性和高的灵敏度，表明该策略是分子疾病的多模式成像和临床前应用的一条简单但有前途的途径。
The rising demand for clinical diagnosis tools has led to extensive research on multimodal bioimaging systems. Unlike single‐modal detection, multimodal imaging not only can provide both function and structure information but also can address the issue of sensitivity, depth, and cost. Despite enormous efforts, conventional step‐by‐step procedures for obtaining multimodal imaging pose a significant constraint on their practical applications. In this work, X‐rays as highly penetrating radiation is proposed as a single‐irradiation resource, while lanthanide‐based nanostructure scintillators are employed as the single contrast agent to attenuate and convert X‐rays, achieving computer tomography (CT) and optical dual‐modal imaging at the same time. In other words, CT and optical dual‐modal imaging are simultaneously produced via single radiation combined with single contrast agent. The function and structure information of targeted tumors in a mouse model can be clearly provided with large penetration and high sensitivity, indicating that this strategy is a simple but promising route for multimodal imaging of molecular disease and preclinical applications.