Antibiotic resistance-the need for global solutions
Antibiotic resistance-the need for global solutions
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DOI：
10.1016/s1473-3099(13)70318-9
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发表时间：
2013-12-01
影响因子：
56.3
通讯作者：
Cars, Otto
中科院分区：
文献类型：
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作者：
Laxminarayan, Ramanan;Duse, Adriano;Cars, Otto
抗生素耐药性的原因很复杂，包括社会许多层面的人类行为;其后果影响到世界上的每个人。与气候变化的相似之处是显而易见的。已经做出了许多努力来描述抗生素耐药性的许多不同方面以及应对挑战所需的干预措施。然而，在国家和国际两级，特别是在政治一级，基本上缺乏协调行动。抗生素为前所未有的医学和社会发展铺平了道路，今天在所有卫生系统中都不可或缺。现代医学的成就，如大手术，器官移植，早产儿治疗和癌症化疗，我们今天认为是理所当然的，如果没有获得有效的治疗细菌感染是不可能的。如果不立即采取真实的和前所未有的全球协调行动，在短短几年内，我们可能会在医疗、社会和经济方面面临可怕的挫折。在此，我们描述了抗生素耐药性的全球状况，其主要原因和后果，并确定了迫切需要采取行动的关键领域。
The causes of antibiotic resistance are complex and include human behaviour at many levels of society; the consequences affect everybody in the world. Similarities with climate change are evident. Many efforts have been made to describe the many different facets of antibiotic resistance and the interventions needed to meet the challenge. However, coordinated action is largely absent, especially at the political level, both nationally and internationally. Antibiotics paved the way for unprecedented medical and societal developments, and are today indispensible in all health systems. Achievements in modern medicine, such as major surgery, organ transplantation, treatment of preterm babies, and cancer chemotherapy, which we today take for granted, would not be possible without access to effective treatment for bacterial infections. Within just a few years, we might be faced with dire setbacks, medically, socially, and economically, unless real and unprecedented global coordinated actions are immediately taken. Here, we describe the global situation of antibiotic resistance, its major causes and consequences, and identify key areas in which action is urgently needed.