Synthesis of a tetrasaccharide substrate of heparanase
Synthesis of a tetrasaccharide substrate of heparanase
复制标题
乙酰肝素酶四糖底物的合成。
DOI：
10.1016/j.carres.2008.06.011
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发表时间：
2008-11-24
影响因子：
3.1
通讯作者：
Yu, Biao
中科院分区：
文献类型：
--
作者：
Chen, Jianfang;Zhou, Ying;Yu, Biao
通过一对双糖构建块的偶联，以聚合的方式合成了与硫酸乙酰肝素酶底物相对应的四糖，即β-D-GICA(2S)-(1-gt；4)-α-D-GIcN(NS，6S)-(1-gt；4)-β-D-GICA-(1-gt；4)-α-D-GIcN(NS，6S)-OMe。(C)2008爱思唯尔有限公司。保留所有权利。
A tetrasaccharide, corresponding to the heparan sulfate heparanase substrate, namely beta-D-GIcA(2S)-(1 -> 4)-alpha-D-GIcN(NS,6S)-(1 -> 4)-beta-D-GIcA-(1 -> 4)-alpha-D-GIcN(NS,6S)-OMe, was synthesized in a convergent manner via coupling of a pair of the disaccharide building blocks as a key step. (C) 2008 Elsevier Ltd. All rights reserved.