Cohort profile:: The Norwegian Mother and Child Cohort Study (MoBa)
Cohort profile:: The Norwegian Mother and Child Cohort Study (MoBa)
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DOI：
10.1093/ije/dyl170
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发表时间：
2006-10-01
影响因子：
7.7
通讯作者：
Stoltenberg, Camilla
中科院分区：
文献类型：
--
作者：
Magnus, Per;Irgens, Lorentz M.;Stoltenberg, Camilla
挪威母亲和儿童队列研究（MoBa）是在1990年代由挪威医学出生登记处（MBRN）的研究人员和国家公共卫生研究所（从2002年起由MBRN和其他机构组成，并更名为挪威公共卫生研究所）的研究人员共同规划的。这项研究有一个漫长的计划阶段，许多科学家参与其中，他们提出了一些想法，帮助设计问卷和构建生物库，这在其他地方有详细描述。2与丹麦出生队列研究（Danish Birth Cohort Study）建立了合作关系，该研究与MoBa同时计划进行。1997年，进行了一项试点研究，招募第一次去看全科医生的孕妇。然而，主要研究没有采用这种数据收集方法，原因是一群全科医生提出抗议，他们反对这项研究的科学价值，并建议妇女过分担心其对疾病风险的关注。由于这些抗议，议会社会委员会命令卫生部在审查这些问题之前放弃进一步的规划。经过委员会1998年的审查，议会投票赞成这项研究。政府提供了启动资金。NIPH决定从小规模开始研究，并在获得资金后扩大研究规模。招聘期间（1999-2008）的总费用估计约为4500万美元。大约三分之二的资金直接来自卫生部和国家卫生研究院。挪威研究理事会很早就决定，它将不支持基本数据收集，但通过一个功能基因组学项目支持DNA提取。其余资金来自国家和国际（美国国立卫生研究院）以及国家卫生研究院的综合项目
The Norwegian Mother and Child Cohort Study (MoBa) was planned in the 1990s partly by researchers at the Medical Birth Registry of Norway (MBRN) 1 and partly by researchers at the National Institute of Public Health (from 2002 comprising MBRN as well as other institutions and renamed the Norwegian Institute of Public Health (NIPH). The study had a long planning phase involving many scientists who contributed ideas that helped to design questionnaires and to structure the biobank, which is described in detail elsewhere. 2 Collaboration was established with the Danish Birth Cohort Study, 3 which was planned in parallel with MoBa. In 1997, a pilot study was undertaken, recruiting pregnant women at their first visit to their general practitioner. However, the main study did not implement this data collection method owing to protests made by a group of general practitioners who argued against the scientific value of the study and suggested that women would be unduly worried by its focus on risks of disease. As a consequence of the protests, the Parliament Social Committee ordered the Ministry of Health to abandon further planning until these issues had been reviewed. After the review by the Committee in 1998, Parliament voted in favour of the study. The government provided seed money. The NIPH decided to commence the study on a small scale and expand as funds became available. The total cost during the recruitment period (1999–2008) has been estimated at~ 45 million dollars. Roughly two-thirds of the funding comes directly from the Ministry of Health and the NIPH. The Research Council of Norway decided early on that it would not support basic data collection but has supported DNA extraction through a programme on functional genomics. The remaining funds have been derived from national and international (National Institutes of Health, USA and integrated projects within the