Development and testing of the KnowGene scale to assess general cancer genetic knowledge related to multigene panel testing
Development and testing of the KnowGene scale to assess general cancer genetic knowledge related to multigene panel testing
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DOI：
10.1016/j.pec.2019.04.014
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发表时间：
2019-08-01
影响因子：
3.5
通讯作者：
Gundersen, Daniel A.
中科院分区：
文献类型：
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作者：
Underhill-Blazey, Meghan;Stopfer, Jill;Gundersen, Daniel A.
目的：为了开发和评估一种措施，癌症遗传学知识相关的多基因面板testing.Methods：该仪器开发使用系统的输入从一个国家小组的遗传学专家，可接受性评价患者的拥护者，和认知测试。在过去的18个月里，591名接受过遗传咨询和多基因面板测试的乳腺或妇科患者完成了24个候选项目。一个一维的项目反应理论模型与2-参数逻辑嵌套反应（2 pinrm）和2-参数逻辑（2 pl）items.Results：解决癌症遗传学知识的关键领域的混合被发现是重叠的。在24个候选项目中，有8个项目因区分度差或局部依赖性而被删除。其余16个项目具有良好的拟合（RMSEA= 0.045，CFI = 0.946）和判别参数范围从0.49到1.60。被指定为2 plnrm的项目区分了那些回答错误和不知道的人，区分度范围从0.51到1.02。信息曲线是最高的那些与较低的knowledge.Conclusion：KnowGene是一个严格的开发和有效的措施后，癌症遗传咨询和多基因面板testing.Practice的影响：测量知识系统的方式将告知癌症遗传学的实践和研究举措。(C)2019年爱思唯尔出版
Purpose: To develop and evaluate a measure of cancer genetics knowledge relevant to multigene panel testing.Methods: The instrument was developed using systematic input from a national panel of genetics experts, acceptability evaluation by patient advocates, and cognitive testing. Twenty-four candidate items were completed by 591 breast or gynecological patients who had undergone genetic counseling and multigene panel testing in the past 18 months. A unidimensional item response theory model was fit with a mix of 2-parameter logistic nested response (2 pinrm) and 2-parameter logistic (2 pl) items.Results: Key domains addressing cancer genetics knowledge were found to be overlapping. Of the 24 candidate items, 8 items were removed due to poor discrimination or local dependence. The remaining 16 items had good fit (RMSEA= 0.045, CFI = 0.946) and discrimination parameters ranging from 0.49 to 1.60. The items specified as 2 plnrm distinguish between those answering incorrect versus don't know, with discrimination ranging from 0.51 to 1.02. Information curves were highest among those with lower knowledge.Conclusion: KnowGene is a rigorously developed and effective measure of knowledge after cancer genetic counseling and multigene panel testing.Practice Implications: Measuring knowledge in a systematic way will inform practice and research initiatives in cancer genetics. (C) 2019 Published by Elsevier B.V.