Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
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DOI：
10.1016/s0006-3223(02)01316-1
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发表时间：
2002-06-15
影响因子：
10.6
通讯作者：
Johnstone, EC
中科院分区：
文献类型：
--
作者：
Lawrie, SM;Buechel, C;Johnstone, EC
背景资料：方法：采用功能磁共振成像（fMRI）技术，对8例精神分裂症患者和10名正常对照者进行了128个视觉呈现句子中缺失的最后一个词的脑功能磁共振成像研究。使用随机效应分析对fMRI数据进行分析，比较句子完成（与休息）的效果。结果：局部大脑反应没有显着的组间差异。左侧颞叶皮层（x =-54，y =-42，z = 3）和左侧背外侧前额叶皮层（x =-39，y = 12，z = 24）的相关系数在精神分裂症组显著降低，且与幻听的严重程度呈负相关。额颞叶功能连接在精神分裂症中减少，可能与幻听有关。生物精神病学2002;51：1008-1011（C）2002生物精神病学学会。
Background: We used functional magnetic resonance imaging (fMRI) to investigate the frontotemporal disconnection hypothesis of schizophrenia.Methods: Eight DSM-IV schizophrenia patients and 10 control subjects were studied with fMRI while they thought of the missing last word in 128 visually presented sentences. The fMRI data were analyzed comparing the effect of sentence completion (vs. rest) using a random effects analysis.Results: There were no significant group differences in regional brain responses. Correlation coefficients between left temporal cortex (x = -54, y = -42, z = 3) and left dorsolateral prefrontal cortex (x = -39, y = 12, z = 24) were significantly lower in the schizophrenic group and were negatively correlated with the severity of auditory hallucinations.Conclusions: Previous demonstrations of hypofrontality in schizophrenia may reflect particular task requirements. Frontotemporal functional connectivity is reduced in schizophrenia and may be associated with auditory hallucinations. Biol Psychiatry 2002;51:1008-1011 (C) 2002 Society of Biological Psychiatry.