PET FDG studies of Wilms tumors.
PET FDG studies of Wilms tumors.
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肾母细胞瘤的 PET FDG 研究。
DOI：
10.1097/00043426-199707000-00012
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Hutchinson,RJ
中科院分区：
文献类型：
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作者：
Shulkin,BL;Chang,E;Strouse,PJ;Bloom,DA;Hutchinson,RJ
目的威尔姆斯瘤是儿童中最常见的肾肿瘤。通常通过解剖成像提示诊断，并通过活检或切除确定诊断。功能成像的主要作用是寻找骨骼转移和评估肾功能。我们假设，像许多肿瘤一样，肾母细胞瘤可以集中 18F-FDG，并且对这些肿瘤的代谢活性的评估可能在临床上有用。材料和方法三名已知或疑似肾母细胞瘤的患者接受了正电子发射断层扫描 (PET)，并使用 2-[氟-18]-氟-2-脱氧-D-葡萄糖 (FDG) 扫描（四次扫描）。一名患有单一肾母细胞瘤的患者在诊断时接受了一次研究。在治疗期间对两名患有双侧肾母细胞瘤的患者进行了研究。结果在诊断时研究的肾母细胞瘤中以及在治疗期间研究的每名双侧疾病患者的一个肿瘤中存在 FDG 的摄取。在所有这三种情况下，PET 扫描的结果都会影响治疗决策。结论 PET FDG 扫描可能有助于治疗选定的肾母细胞瘤患者。
PurposeWilms tumor is the most common renal neoplasm in children. The diagnosis is usually suggested by anatomic imaging and established by biopsy or resection. The principal roles of functional imaging have been the search for skeletal metastases and evaluation of renal function. We hypothesized that, like many tumors, Wilms tumors could concentrate 18F-FDG and that evaluation of the metabolic activity of these neoplasms might prove clinically useful.Materials and MethodsThree patients with known or suspected Wilms tumors underwent positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) scanning (four scans). A patient with a single Wilms tumor was studied once at the time of diagnosis. The two patients with bilateral Wilms tumors were studied during therapy.ResultsUptake of FDG was present in the Wilms tumor studied at diagnosis, and in one of the tumors in each of the patients with bilateral disease studied during therapy. In all three cases, the results of the PET scans influenced therapeutic decisions.ConclusionPET FDG scanning may be useful for the management of selected patients with Wilms tumors.