American Ginseng and Asian Ginseng Intervention in Diet-Induced Obese Mice: Metabolomics Reveals Distinct Metabolic Profiles
American Ginseng and Asian Ginseng Intervention in Diet-Induced Obese Mice: Metabolomics Reveals Distinct Metabolic Profiles
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西洋参和亚洲人参对饮食诱导的肥胖小鼠的干预：代谢组学揭示了不同的代谢特征
DOI：
10.1142/s0192415x19500411
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发表时间：
2019
影响因子：
5.7
通讯作者：
Liu Qun
中科院分区：
文献类型：
--
作者：
Zhang Wen Song;Pan An;Yang Liu;Cai Yuan Yuan;Liu Bao Lin;Li Ping;Qi Lian Wen;Li Jing;Liu Qun
西洋参和亚洲人参在西方和东方畅销天然产品排行榜上占有突出地位，在传统药理用途中适合不同的适应症。目前，西洋参和亚洲人参对代谢紊乱的保护作用以及它们之间的差异尚不清楚。为此，建立了一种基于LC-Q-TOF-MS的非靶向代谢组学方法。血清代谢组学和动态粪便代谢组学结果显示，西洋参和亚洲人参在饮食诱导肥胖(DIO)小鼠体内的代谢存在显著差异。结果表明，西洋参和亚洲人参对DIO小鼠糖脂代谢紊乱有一定的缓解作用。药用朴素组与西洋参组共鉴定出45种差异代谢物，药用朴素组与亚参组鉴定出32种代谢产物。代谢途径分析表明，这两种人参皂苷治疗动态纠正DIO小鼠代谢紊乱主要是通过调节亚油酸代谢、半胱氨酸和蛋氨酸代谢以及不饱和脂肪酸的生物合成。此外，西洋参在监测肉碱和牛磺酸/次牛磺酸代谢方面的独特功能可能使其在改善脂代谢紊乱方面比亚洲人参更有效。
American ginseng and Asian ginseng, which occupy prominent positions in the list of best-selling natural products in the West and East, are suitable for different indications in the traditional pharmacological uses. Currently, the effects of American ginseng and Asian ginseng in the protection against metabolic dysfunction and the differences between them are still unknown. Herein, an untargeted metabolomics based on liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) was determined. The serum metabolomics and dynamic feces metabolomics revealed significant metabolic distinction between American ginseng and Asian ginseng in diet-induced obese (DIO) mice. The results show that American ginseng and Asian ginseng alleviate glucose and lipid metabolism disorder in DIO mice. A total of 45 differential metabolites were confirmed between the drug-naïve and American ginseng group, and 32 metabolites were confirmed between the drug-naïve and Asian ginseng group. Metabolic pathways analysis shows that these two ginsengs treatment dynamic rectifies metabolic disorder in DIO mice mainly via regulating linoleic acids metabolism, cysteine and methionine metabolism and biosynthesis of unsaturated fatty acid. Moreover, American ginseng’s specific function in monitoring the carnitines and taurine/hypotaurine metabolism might make it more effective in meliorating lipids metabolism disorder than Asian ginseng.