Antiangiogenic and antitumor effects of tranilast on mouse lung carcinoma cells.
Antiangiogenic and antitumor effects of tranilast on mouse lung carcinoma cells.
复制标题
曲尼司特对小鼠肺癌细胞的抗血管生成和抗肿瘤作用。
DOI：
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发表时间：
2000
影响因子：
5.2
通讯作者：
S. Hayashi
中科院分区：
文献类型：
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作者：
J. Yatsunami;S. Aoki;Y. Fukuno;Y. Kikuchi;M. Kawashima;S. Hayashi
本研究观察了曲尼司特对小鼠刘易斯肺癌和C57 BL小鼠肿瘤血管生成、肿瘤生长和转移的影响。在小鼠背气囊血管生成模型中，曲尼司特显著减少由刘易斯肺癌细胞诱导的致密毛细血管网络。腹膜内给予200 mg/kg/天的曲尼司特可使小鼠刘易斯肺癌的肿瘤大小减小至对照组的约63%，并抑制自发系统中的肺转移。免疫组化显示曲尼司特在体内可减少肿瘤血管的生成，增加肿瘤细胞的凋亡。曲尼司特能增强环磷酰胺、顺铂、阿霉素和长春地辛对肿瘤生长的抑制作用。这些结果表明曲尼司特具有抗血管生成和抗肿瘤作用，可能具有潜在的治疗应用。
We examined the effects of tranilast on tumor angiogenesis, tumor growth and metastasis in the mouse Lewis lung carcinoma and C57BL mouse system. Tranilast significantly reduced the dense capillary network induced by Lewis lung cancer cells in a mouse dorsal air sac angiogenesis model. Intraperitoneal administration of tranilast at 200 mg/kg/day reduced the tumor size of mouse Lewis lung carcinoma to about 63% of that of the control and suppressed pulmonary metastasis in a spontaneous system. Immunohistochemistry revealed that tranilast reduced the tumor vascularity and increased apoptosis of the tumor cells in vivo. Tranilast potentiated the inhibition of the tumor growth induced by cyclophosphamide, cis-diamminedichloroplatinum(II), adriamycin and vindesine in vivo. These results suggest that tranilast has antiangiogenic and antitumor effects and might have possible therapeutic applications.