Analogous functions of macrophages and Langerhans cells in the initiation in the immune response.
Analogous functions of macrophages and Langerhans cells in the initiation in the immune response.
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巨噬细胞和朗格汉斯细胞在免疫反应启动中具有类似的功能。
DOI：
10.1111/1523-1747.ep12544055
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
I. Green
中科院分区：
文献类型：
--
作者：
G. Stingl;S. Katz;E. Shevach;A. Rosenthal;I. Green
朗格汉斯细胞构成哺乳动物表皮内的小细胞群。本文从免疫学和功能上对这些细胞进行了定义，并支持朗格汉斯细胞与单核细胞-巨噬细胞-组织细胞系列细胞密切相关的概念。两种细胞类型都具有Fc-IgG和C3的表面受体，并表达被称为Ia抗原的表面糖蛋白，其由物种的主要组织相容性复合体的免疫应答基因（Ir基因）编码。朗格汉斯细胞和巨噬细胞表达Ia抗原与这两种细胞类型的重要功能密切相关，包括向T淋巴细胞呈递免疫相关抗原和在混合白细胞反应中引起同种异体T淋巴细胞增殖的能力。
Langerhans cells constitute a minor cell population within the mammalian epidermis. This paper defines these cells immunologically and functionally and supports the concept that Langerhans cells are closely related to cells from the monocyte-macrophage-histiocyte series. Both cell types bear surface receptors for Fc-IgG and C3 and express surface glycoproteins, termed Ia antigens, encoded for by immune-response genes (Ir genes) of the major histocompatibility complex of the species. The expression of Ia antigens by Langerhans cells and macrophages is intimately associated with important functions of both cell types, including the capacity to present immunologically relevant antigen to the T lymphocyte and to cause proliferation to allogeneic T lymphocytes in mixed leukocyte reactions.