Electron microscopic observations on the structure of the rat adrenal medulla: II. Normal innervation.
Electron microscopic observations on the structure of the rat adrenal medulla: II. Normal innervation.
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发表时间：
1965-04
影响因子：
2.4
通讯作者：
Byr R. E. Coupland
中科院分区：
文献类型：
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作者：
Byr R. E. Coupland
现在普遍认为肾上腺染色质细胞接受神经节前交感神经支配。这些纤维大部分通过胸大植神经进入腺体；较少数量的纤维可穿过胸小内脏神经或从前两个腰神经节穿过（Young, 1939; Maycock & Heslop, 1939）。自Fusari（1891）的早期观察以来，许多工作者描述了肾上腺髓神经纤维的分布。索尼（如Fusari, 1891; Alpert, 1931; Willard, 1936; Hollinshead, 1936）描述了不同的神经末梢与染色质细胞的关系。其他人（Stohr， 1935年，1955年；Sato， 1952年）描述了终网，而Hillarp（1946年，1959年）在肾上腺髓质中发现了与许旺细胞胞浆相关的神经纤维，但没有发现明显的神经末梢或终网的证据。Coupland & Holmes（1958）利用银浸和胆碱脂酶组织化学技术证明了猫、兔和大鼠肾上腺髓质中细小的神经纤维与支持雪旺细胞成分相关，这项工作最近已扩展到牛和人（Coupland, 1961）。在胆碱酯酶处理的组织中，细小的神经纤维从神经轴突和相关的雪旺细胞组成的粗糙的三维网络延伸到邻近的染色质细胞。在染色质细胞附近，它们表现出与Willard（1936）描述的“通道钮扣”和“终端钮扣”相似的肿胀。虽然早期关于肾上腺髓质电子显微镜的报道（Lever, 1955; Wetzstein, 1957; De Robertis & Vaz Ferreira, 1957）提到了神经纤维和神经末梢在染色质细胞上的存在，但很少给出细节。在目前工作的初步报告中（Coupland, 1962, 1963）描述了大鼠肾上腺染色质细胞的突触型末梢。现在手头的材料使我们有可能对大鼠肾上腺髓质的神经纤维和支持元素的排列和分布给出更完整和详细的描述。
It is now generally accepted that adrenal chromaflin cells receive a preganglioniic sympathetic innervation. The majority of these fibres pass to the gland by way of the great thoracic splanchnic nerve; smaller numbers of fibres may traverse the lesser thoracic splanchnic nerve or pass from the first two lumbar ganglia (Young, 1939; Maycock & Heslop, 1939). Since the early observations of Fusari (1891) many workers have described the distribution of adrenal medullary nerve fibres. Sonie (e.g. Fusari, 1891; Alpert, 1931; Willard, 1936; Hollinshead, 1936) described distinct nerve endings in relation to chromaffin cells. Others (Stohr, 1935, 1955; Sato, 1952) described a terminal reticulum, while Hillarp (1946, 1959) identified nerve fibres in association with a Schwann cell plasmodium in the adrenal medulla, but did not find evidence of either distinct nerve endings or a terminal reticulum. Using silver impregnation and cholinesterase histochemical techniques Coupland & Holmes (1958) demonstrated fine nerve fibres in association with supporting Schwann cell elements in the adrenal medulla of cat, rabbit and rat and this work has been extended more recently to ox and man (Coupland, 1961). In tissues processed for cholinesterase, fine nerve fibres have been observed running from a coarse three-dimensional network of nerve axons and associated Schwann cells to adjacent chromaffin cells. In the vicinity of the chromaffin cells they exhibit swellings of a similar nature to those described by Willard (1936) as boutons de passage and terminal boutons. Although earlier reports on the electron microscopy of the adrenal medulla (Lever, 1955; Wetzstein, 1957; De Robertis & Vaz Ferreira, 1957) referred to the presence of nerve fibres and nerve endings on chromaffin cells, few details were given. In preliminary reports on the current work (Coupland, 1962, 1963) synaptictype endings were described on adrenal chromaffin cells in the rat. Material now to hand makes it possible to give a more complete and detailed picture of the arrangement and distribution of nerve fibres and supporting elements in the rat adrenal medulla.