Optical property recovery with spatially-resolved diffuse reflectance at short source-detector separations using a compact fiber-optic probe
Optical property recovery with spatially-resolved diffuse reflectance at short source-detector separations using a compact fiber-optic probe
复制标题
DOI：
10.1364/boe.443332
复制
发表时间：
2021-12-01
影响因子：
3.4
通讯作者：
Baran, Timothy M.
中科院分区：
文献类型：
--
作者：
Bridger, Karina G.;Roccabruna, Jacob R.;Baran, Timothy M.
我们描述了一个紧凑的光纤探头（2毫米外径），利用spatiallresolved漫反射组织光学特性恢复。在含有Intraperid20%作为散射体，亚甲蓝（MB）、MnTPPS和/或印度油墨作为吸收体的体模中进行验证。在一系列条件下，还原散射系数恢复与均方根误差（RMSE）为0.86 - 2.7厘米（-1）（平均误差= 3.8%）。MB浓度回收率为RMSE = 0.26 - 0.52 μ M（平均误差= 15.0%），其不随MnTPPS的加入而变化（p = 0.65）。该系统将被用来确定人体皮肤的光学特性，以产生用于光动力疗法的治疗计划。(C)根据OSA开放获取出版协议的条款，2021年美国光学学会
We describe a compact fiber-optic probe (2 mm outside diameter) that utilizes spatiallyresolved diffuse reflectance for tissue optical property recovery. Validation was performed in phantoms containing Intralipid 20% as scatterer, and methylene blue (MB), MnTPPS, and/or India ink as absorbers. Over a range of conditions, the reduced scattering coefficient was recovered with a root mean square error (RMSE) of 0.86-2.7 cm(-1) (average error = 3.8%). MB concentration was recovered with RMSE = 0.26-0.52 mu M (average error = 15.0%), which did not vary with inclusion of MnTPPS (p=0.65). This system will be utilized to determine optical properties in human abscesses, in order to generate treatment plans tbr photodynamic therapy. (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement