INTERLEUKIN-1 STIMULATION OF ASTROGLIAL PROLIFERATION AFTER BRAIN INJURY
INTERLEUKIN-1 STIMULATION OF ASTROGLIAL PROLIFERATION AFTER BRAIN INJURY
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DOI：
10.1126/science.3872478
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
LACHMAN, LB
中科院分区：
文献类型：
--
作者：
GIULIAN, D;LACHMAN, LB
白细胞介素在免疫功能中具有调节作用，也可能介导与脑损伤相关的炎症。在实验中，以确定这些肽类激素对培养的神经胶质细胞增殖的影响，白细胞介素1是一个强大的有丝分裂原星形胶质细胞，但对少突胶质细胞没有影响。白细胞介素2没有改变任何类型的神经胶质细胞的生长。在脑损伤后10天，在成年大鼠脑中检测到类似于白细胞介素1的活性。炎症细胞释放的白细胞介素1可能促进受损哺乳动物大脑中星形胶质细胞形成瘢痕。
The interleukins, which have a regulatory role in immune function, may also mediate inflammation associated with brain injury. In experiments to determine the effect of these peptide hormones on glial cell proliferation in culture, interleukin 1 was a potent mitogen for astroglia but had no effect on oligodendroglia. Interleukin 2 did not alter the growth of either type of glial cell. Activity similar to that of interleukin 1 was detected in brains of adult rats 10 days after the brains had been injured. Interleukin 1, released by inflammatory cells, may promote the formation of scars by astroglia in the damaged mammalian brain.