Janohigenins: Long-chain anacardic acid derivatives with neuroprotective activity from Ophiopogon japonicus seeds
Janohigenins: Long-chain anacardic acid derivatives with neuroprotective activity from Ophiopogon japonicus seeds
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DOI：
10.1016/j.phytochem.2021.112904
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发表时间：
2021-08-10
期刊：
影响因子：
3.8
通讯作者：
Ishihara, Yasuhiro
中科院分区：
文献类型：
--
作者：
Ohta, Shinji;Takeda, Manami;Ishihara, Yasuhiro
从麦冬种子胚乳中分离得到8个迄今未见的长链无心梗酸衍生物janohigenins，并利用光谱学和化学方法对其结构进行了鉴定。研究了分离化合物对鱼藤酮诱导的SH-SY5Y人神经母细胞瘤细胞损伤的神经保护活性。Janohigenins在1 μ M时表现出明显的神经保护作用。
Eight hitherto undescribed long-chain anacardic acid derivatives, janohigenins, were isolated from the endosperm of Ophiopogon japonicus seed, and their structures were elucidated employing spectroscopic and chemical methods. The neuroprotective activity of the isolated compounds was evaluated against rotenone-induced cellular damage in SH-SY5Y human neuroblastoma cells. Janohigenins exhibited noticeable neuroprotection at 1 mu M.