High association of human papillomavirus infection with oral cancer:: A case-control study
High association of human papillomavirus infection with oral cancer:: A case-control study
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DOI：
10.1016/j.arcmed.2007.08.003
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发表时间：
2008-02-01
影响因子：
7.7
通讯作者：
Garcia-Carranca, Alejandro
中科院分区：
文献类型：
--
作者：
Anaya-Saavedra, Gabriela;Ramirez-Amador, Velia;Garcia-Carranca, Alejandro
背景本研究的目的是确定墨西哥个体中高危型人乳头瘤病毒（HR-HPV）与口腔鳞状细胞癌（OSCC）及其与各种危险因素的关系。我们设计了一个配对的病例对照研究。病例为新诊断的OSCC患者，年龄和性别与对照组匹配（1：4）。获得了人口统计学和临床数据，还包括一份关于性行为的自填问卷。纯化口腔刷拭DNA，通过MY 09/MY 11和GP 5 +/GP 6+引物扩增HPV-DNA，随后进行测序。建立条件回归模型，计算OR值和95%可信区间。纳入62例病例和248例对照（53.2%男性），中位年龄62岁（Q1-Q3 = 54-72岁）。HPV感染率在病例组为43.5%，对照组为17.3%（HR-HPV：病例组37.1%，对照组9.7%）。HPV-16型和HPV-18型最常见（55.6%和18.5%）。HR-HPV的存在与OSCC相关（OR = 6.2; 95%CI：2.98-12.97），控制了最常见的危险因素。检测到吸烟和饮酒之间存在相互作用，癌症家族史也显着（OR：3.61; 95%CI = 1.44-8.99）。初次性交年龄小和一生中有大量性伴侣与HR-HPV相关（p = 0.019和p = 0.001）。033）.结论。口腔HR-HPV与OSCC密切相关，表明HPV-16和-18是墨西哥患者口腔癌的危险因素。烟草和酒精之间的显著关联得到了证实。此外，癌症家族史也与此相关。口腔鳞癌。研究结果强调了HPV在口腔鳞癌中的作用及其多因素病因学。(C)2008年IMSS。爱思唯尔公司出版
Background. The aim of the present study was to determine the association of high-risk human papillomavirus (HR-HPV) in Mexican individuals with oral squamous cell carcinoma (OSCC) and their association with various risk factors.Methods. We designed a matched case-control study. Cases were individuals with newly diagnosed OSCC, age- and sex-matched with controls (1:4). Demographic and clinical data were obtained; also a self-administered questionnaire about sexual behavior was included. DNA from oral brushing was purified to amplify HPV-DNA through MY09/MY11 and GP5+/GP6+ primers and subsequently subjected to sequencing. Conditional regression models were built to calculate odds ratios (ORs) and 95% confidence intervals (CI).Results. Sixty two cases and 248 controls (53.2% males), median age 62 years (Q1-Q3 = 54-72 years) were included. HPV prevalence was 43.5% in cases and 17.3% in controls (HR-HPV: 37.1% cases, 9.7% controls). The most frequent types in cases were HPV-16 and HPV-18 (55.6 and 18.5%). The presence of HR-HPV was associated with OSCC (OR = 6.2; 95% CI: 2.98-12.97) controlling for the most common risk factors. An interaction between smoking and drinking was detected, and family history of cancer was also significant (OR: 3.61; 95% CI = 1.44-8.99). Early age at first sexual intercourse and large number of lifetime sexual partners showed an association with HR-HPV (p = 0.019 and p = 0..033, respectively).Conclusions. Oral HR-HPV was strongly associated with OSCC, suggesting that HPV-16 and -18 are risk factors for oral cancer in Mexican patients. A significant association of tobacco and alcohol was confirmed. In addition, family history of cancer was associated with. OSCC. The results underline the role of HPV in OSCC and its multifactorial etiology. (C) 2008 IMSS. Published by Elsevier Inc.