Elevated baseline plasma phospholipid protein (PLTP) levels are an independent predictor of long-term all-cause mortality in patients with diabetes mellitus and known or suspected coronary artery disease.
Elevated baseline plasma phospholipid protein (PLTP) levels are an independent predictor of long-term all-cause mortality in patients with diabetes mellitus and known or suspected coronary artery disease.
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DOI：
10.1016/j.atherosclerosis.2015.02.017
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发表时间：
2015-04
期刊：
影响因子：
5.3
通讯作者：
Jiang, Xian-Cheng
中科院分区：
文献类型：
--
作者：
Cavusoglu, Erdal;Marmur, Jonathan D.;Chhabra, Sandeep;Hojjati, Mohammad R.;Yanamadala, Sunitha;Chopra, Vineet;Eng, Calvin;Jiang, Xian-Cheng
关键词：
目的：探讨基础血浆PLTP水平对一组确诊或可疑冠状动脉造影的男性糖尿病患者的长期预后意义。PLTP是一种血浆蛋白，介导脂蛋白之间磷脂的净转移和交换。它与动脉粥样硬化的发病机制有关，有报道称糖尿病患者的血浆水平升高。对154例接受冠状动脉造影术的男性糖尿病患者进行了基线血浆PLTP水平的测定，并对其进行了5年的前瞻性追踪，以了解其全因死亡率的发展。在调整了各种基线临床、血管造影和实验室参数后，血浆PLTP水平(作为连续变量分析)是5年全因死亡率的独立预测因子(HR，1.55；95%CI，1.22-2.00；P=0.0009)。此外，在另外3个多变量模型中，PLTP仍然是5年内全因死亡率的独立预测因子，这些模型还包括多种现代生物标志物，它们对预后有明确的预测作用(即ST2、GDF-15、Cystatin C、纤维蛋白原和NT-proBNP)。基线血浆PLTP水平升高与糖尿病和已知或可疑冠心病患者长期全因死亡的风险增加相关。此外，这种相关性独立于各种临床、血管造影和实验室变量，包括一系列具有既定预后疗效的当代生物标记物。
To investigate the long-term prognostic significance of baseline plasma PLTP levels in a group of well-characterized male patients with diabetes mellitus and known or suspected coronary artery disease referred for coronary angiography. PLTP is a plasma protein that mediates net transfer and exchange of phospholipids between lipoproteins. It has been implicated in the pathogenesis of atherosclerosis and elevated plasma levels have been reported in patients with diabetes mellitus. Baseline plasma PLTP levels were measured in 154 male patients with diabetes mellitus who were referred for coronary angiography and followed prospectively for the development of all-cause mortality for 5 years. After adjustment for a variety of baseline clinical, angiographic and laboratory parameters, plasma PLTP levels (analyzed as a continuous variable) were an independent predictor of all-cause mortality at 5 years (HR, 1.55; 95% CI, 1.22–2.00; P=0.0009). Furthermore, in 3 additional multivariate models that also included a wide variety of contemporary biomarkers with established prognostic efficacy (i.e., ST2, GDF-15, Cystatin C, Fibrinogen, and NT-proBNP), PLTP remained an independent predictor of all-cause mortality at 5 years. Elevated baseline plasma levels of PLTP are associated with an increased risk of long-term all-cause mortality in patients with diabetes and known or suspected coronary disease. Furthermore, this association is independent of a variety of clinical, angiographic, laboratory variables, including a whole host of contemporary biomarkers with established prognostic efficacy.
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影响因子：
7.7
作者：
Colhoun, HM;Taskinen, MR;Van Tol, A
通讯作者：
Van Tol, A
影响因子：
11.1
作者：
Dullaart, R. P. F.;Vergeer, M.;Dallinga-Thie, G. M.
通讯作者：
Dallinga-Thie, G. M.
影响因子：
82.9
作者：
Jiang, XC;Qin, SC;Tall, AR
通讯作者：
Tall, AR
DOI：
10.1016/0005-2760(84)90156-5
发表时间：
1984-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
MASSEY, JB;HICKSON, D;POWNALL, HJ
通讯作者：
POWNALL, HJ
影响因子：
6.8
作者：
Bruce, C;Beamer, LJ;Tall, AR
通讯作者：
Tall, AR