In-vivo and in-vitro screening of medicinal plants for their anti-inflammatory activity: an overview
In-vivo and in-vitro screening of medicinal plants for their anti-inflammatory activity: an overview
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药用植物抗炎活性的体内和体外筛选：概述
DOI：
10.7324/japs.2012.2704
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发表时间：
2012
影响因子：
--
通讯作者：
Bhoomi Patel
中科院分区：
文献类型：
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作者：
M. Phanse;M. Patil;K. Abbulu;P. Chaudhari;Bhoomi Patel
尽管过去几十年来医学研究取得了进展，但许多严重疾病的治疗仍然存在问题。炎症是活组织对损伤的反应。它涉及一系列复杂的酶激活、介质释放、液体外渗、细胞迁移、组织分解和修复。炎症已成为全球科学研究的焦点，因为它涉及几乎所有的人类和动物疾病。由于非甾体类抗炎药（NSAID）引起的胃损伤、阿片类药物引起的耐受性和依赖性等不良反应，使用这些药物作为镇静剂并非在所有情况下都取得成功。因此，正在研究没有这些副作用的新抗炎药作为NSAID和阿片类药物的替代品。传统医药中使用的植物源药物因其价格便宜、副作用小而受到人们的关注。因此，在本综述中，各种动物模型用于临床前筛选抗炎活性的草药。
Despite the progress made in medical research for the past decades, the treatment of many serious diseases is still problematic. Inflammation is the response of living tissues to injury. It involves a complex array of enzyme activation, mediator release, extravasations of fluid, cell migration, tissue breakdown and repair. Inflammation has become the focus of global scientific research because of its implication in virtually all human and animal diseases. As a result of adverse effects such as gastric lesions caused by non-steroidal anti-inflammatory drugs (NSAID), tolerance and dependence induced by opiates, the use of these drugs as antiinflammatory agents have not been successful in all cases. Therefore, new anti-inflammatory drugs lacking these side effects are being researched as alternatives to NSAID and opiates. Attention is being focused on the investigation of the efficacy of plant-based drugs used in the traditional medicine because they are cheap, have little side effects. Hence, in the present review the various animal models used for preclinical screening anti-inflammatory activity herbs was compiled.