Estrogen Receptors in Ovarian Epithelial Carcinoma
Estrogen Receptors in Ovarian Epithelial Carcinoma
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DOI：
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发表时间：
1982-02
影响因子：
7.2
通讯作者：
P. E. Schwartz;V. Livolsi;N. Hildreth;N. MacLusky;Naftolin Fn;A. Eisenfeld
中科院分区：
文献类型：
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作者：
P. E. Schwartz;V. Livolsi;N. Hildreth;N. MacLusky;Naftolin Fn;A. Eisenfeld
1976年10月至1979年2月期间，53%(16/30)未经治疗的卵巢上皮癌患者的雌激素结合水平高于30fmoles/mg胞浆蛋白(富含受体)。标本富含受体的可能性似乎与患者的年龄、肿瘤的组织学分级、临床分期和手术后残留肿瘤的数量无关。对于20名以前未接受治疗的晚期疾病患者，生命表分析显示，当受试者丰富的组和贫乏组在存活率或疾病首次进展的时间方面进行比较时，没有显着差异。对较新的样本(主要是在1979年2月之后获得的)的分析表明，雌激素与受体的高亲和力结合；不同肿瘤受累部位之间的雌激素结合结果偶尔存在显著的异质性；在一些样本中，孕激素特异性结合。与乳腺癌类似，肿瘤细胞浆雌激素受体丰富的患者理论上可能对服用抗雌激素药物有反应。
Specimens from 53% (16 of 30) of patients with untreated ovarian epithelial cancers between October 1976 and February 1979 had estrogen binding levels greater than 30 fmoles/mg of cytosol protein (receptor rich). The likelihood of a specimen being receptor rich appeared to be independent of patient age, histologic grade of tumor, clinical stage, and amount of residual tumor left after surgery. For 20 patients with previously untreated advanced disease a life-table analysis showed no significant difference when receptorrich and -poor groups were compared in terms of either survival or time to first progression of disease. Analysis of more recent specimens (predominantly obtained after February 1979) indicates high-affinity binding of the estrogen consistent with receptor; occasional substantial heterogeneity in estrogen binding results between different sites of tumor involvement; and progestin-specific binding in some specimens. In an analogy to breast cancer, patients whose tumors are cytosol estrogen receptor rich might theoretically be responsive to the administration of antiestrogens.