Locomotion Induces Stimulus-Specific Response Enhancement in Adult Visual Cortex
Locomotion Induces Stimulus-Specific Response Enhancement in Adult Visual Cortex
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DOI：
10.1523/jneurosci.3760-16.2017
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发表时间：
2017-03-29
影响因子：
5.3
通讯作者：
Stryker, Michael P.
中科院分区：
文献类型：
--
作者：
Kaneko, Megumi;Fu, Yu;Stryker, Michael P.
The responses of neurons in the visual cortex (V1) of adult mammals have long been thought to be stable over long periods. Here, we investigated whether repeated exposure to specific stimuli would enhance V1 visual responses in mice using intrinsic signal imaging through the intact skull and two-photon imaging of calcium signals in single neurons. Mice ran on Styrofoam balls floating on air while viewing one of three different, high-contrast visual stimuli. V1 responses to the stimuli that were viewed by the animal were specifically enhanced, while responses to other stimuli were unaffected. Similar exposure in stationary mice or in mice in which NMDA receptors were partially blocked did not significantly enhance responses. These findings indicate that stimulus-specific plasticity in the adult visual cortex depends on concurrent locomotion, presumably as a result of the high-gain state of the visual cortex induced by locomotion.
