Cotinine in meconium indicates risk for early respiratory tract infections
Cotinine in meconium indicates risk for early respiratory tract infections
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DOI：
10.1191/096032799678840057
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发表时间：
1999-04-01
影响因子：
2.8
通讯作者：
Rieger, CHL
中科院分区：
文献类型：
--
作者：
Nuesslein, TG;Beckers, D;Rieger, CHL
1 为了确定婴儿早期下呼吸道症状的潜在风险，测量了 91 名新生儿胎便中的可替宁浓度，作为产前烟草暴露的参数，并在出生时对父母进行了问卷调查。通过每月电话访谈对婴儿出生后的第一年进行随访。2 出生后前 6 个月的下呼吸道感染与胎便中高浓度的可替宁有关（可替宁高于中位数 vs 低于中位数；比值比 4.9，95% 置信区间 1.2 至 20.3），而没有测试其他变量，包括父母、产前或产后烟草消费的自我报告、父母过敏史、母亲年龄、在场情况兄弟姐妹、社会经济地位、妊娠持续时间、出生体重、性别和母乳喂养持续时间被确定为独立风险。通过胎便中可替宁排泄量超过组中位数，可以正确预测 77% 的婴儿在出生后前 6 个月内会发生下呼吸道感染。3 总之，胎便中可替宁的定量优于历史参数，可作为早期呼吸道感染风险的估计。
1 In order to identify potential risks for lower respiratory tract symptoms during early infancy, the concentration of cotinine was measured in meconium of 91 newborns as a parameter of prenatal exposure to tobacco, and a questionnaire was performed with parents at birth. Infants were followed up for the first year of life by monthly telephone interviews.2 Lower respiratory tract infections during the first 6 months of life were associated with a high concentration of cotinine in meconium (cotinine higher than median vs lower than median; odds ratio 4.9, 95% confidence interval 1.2 to 20.3), while none of the other variables tested including selfreport of parental, prenatal or postnatal tobacco consumption, parents history of atopy, maternal age, presence of siblings, socio-economic status, duration of gestation, birth weight, gender, and duration of breast feeding were identified as independent risks. The occurrence of a lower respiratory tract infection during the first 6 months of life was predicted correctly in 77% of the infants by a cotinine excretion in meconium exceeding the group median.3 In conclusion, quantification of cotinine in meconium is preferred to historical parameters as an estimate of the risk for early respiratory tract infections.