INTERACTION OF PANCREATIC DUCTAL CARCINOMA WITH NERVES LEADS TO NERVE DAMAGE
INTERACTION OF PANCREATIC DUCTAL CARCINOMA WITH NERVES LEADS TO NERVE DAMAGE
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DOI：
10.1016/0016-5085(94)90080-9
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发表时间：
1994-07-01
期刊：
影响因子：
29.4
通讯作者：
BEGER, HG
中科院分区：
文献类型：
--
作者：
BOCKMAN, DE;BUCHLER, M;BEGER, HG
背景/目的：胰腺癌的神经周围延伸被解释为沿阻力最小平面沿着的机械性延伸。本研究测试是否癌症是有限的，以遵循这些飞机，如果参与细胞信号传导的物质参与癌细胞与nerves.Methods的相互作用：胰腺癌切除患者的组织样品进行了研究，通过电子显微镜和光学显微镜。结果：腺癌不局限于神经周围，在神经周围有转化生长因子α（TGF-α）和表皮生长因子受体（EGFR）表达。它穿透神经束膜并与神经内膜中的许旺细胞和轴突密切相关。神经元件受损。神经侵入可能是相关疼痛的一个因素。TGF-α在胰腺的神经中丰富。结论：胰腺癌与神经的相互作用比神经周围间隙癌更广泛。神经中的TGF-α与癌细胞上的EGFR的相互作用构成了一种可能的旁分泌机制，其为胰腺癌提供了生长优势，并作为可能在癌症与神经的生物学相互作用中具有活性的潜在相互作用的示例。
Background/Aims:Perineural extension of pancreatic adenocarcinoma has been explained as a mechanical extension along planes of least resistance. This study tests whether the cancer is limited to following these planes and if substances involved in cell signaling are involved in the interaction of cancer cells with nerves.Methods:Samples of tissue from patients undergoing resection of pancreatic cancer were studied by electron microscopy and light microscopy. Transforming growth factor α (TGF-α) and epidermal growth factor receptor (EGFR) were localized in sections.Results:The adenocarcinoma is not confined to the periphery of nerves. It penetrates the perineurium and becomes intimately associated with Schwann cells and axons in the endoneurium. Neural elements are damaged. Neural invasion likely is a factor in associated pain. TGF-α is abundant in nerves in the pancreas. EGFR is prominent in the cells of the adenocarcinoma.Conclusions:The interaction of pancreatic cancer with nerves involves more than the cancer following a perineural space. Interaction of TGF-α in nerves with EGFR on cancer cells constitutes a possible paracrine mechanism that provides a growth advantage for pancreatic adenocarcinoma and serves as an example of potential interactions that might be active in biological interaction of cancer with nerves.