Differences in the distribution of subtypes according to the WHO classification 2008 between Japanese and German patients with refractory anemia according to the FAB classification in myelodysplastic syndromes
Differences in the distribution of subtypes according to the WHO classification 2008 between Japanese and German patients with refractory anemia according to the FAB classification in myelodysplastic syndromes
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DOI：
10.1016/j.leukres.2009.11.015
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发表时间：
2010-08-01
影响因子：
2.7
通讯作者：
Tomonaga, Masao
中科院分区：
文献类型：
--
作者：
Matsuda, Akira;Germing, Ulrich;Tomonaga, Masao
我们报告了日本和德国难治性贫血(RA)患者在FAB分类中的不同临床特征。我们根据2008年修订的WHO分类重新分析其临床特征。日本患者难治性细胞减少伴单核细胞异常增殖症和骨髓增生异常综合征未分类伴全血细胞减少的发生率高于德国患者(p<；0.001)。在这两个国家中，难治性红细胞减少伴多系发育不良患者的预后最差。日本患者中MDS-U合并全血细胞减少和RCUD的频率较高，可能影响了日本和德国FAB-RA患者不同的临床特征。(C)2009爱思唯尔有限公司。保留所有权利。
We reported the different clinical features between Japanese and German refractory anemia (RA) patients in FAB classification. We re-analyzed the clinical features by WHO classification revised in 2008. The frequencies of refractory cytopenia with unilineage dysplasia (RCUD) and myelodysplastic syndrome-unclassified (MDS-U) with pancytopenia in Japanese patients were higher than in German patients (p < 0.001). Refractory cytopenia with multilineage dysplasia patients showed the most unfavorable prognosis in both countries. The higher frequencies of MDS-U with pancytopenia and RCUD in Japanese patients may influence the different clinical characteristics between Japanese and German FAB-RA patients. (C) 2009 Elsevier Ltd. All rights reserved.