A skin-inspired organic digital mechanoreceptor
A skin-inspired organic digital mechanoreceptor
复制标题
DOI：
10.1126/science.aaa9306
复制
发表时间：
2015-10-16
期刊：
影响因子：
56.9
通讯作者：
Bao, Zhenan
中科院分区：
文献类型：
--
作者：
Tee, Benjamin C. -K.;Chortos, Alex;Bao, Zhenan
人类皮肤依赖于皮肤受体，皮肤受体输出用于触觉感测的数字信号，其中刺激的强度被转换为一系列电压脉冲。我们提出了一种高效的皮肤激励机械感受器与灵活的有机晶体管电路，直接转换成数字频率信号的压力。输出频率范围在0到200赫兹之间，对模拟缓慢适应皮肤机械感受器的力刺激的次线性响应。传感器的输出进一步用于刺激体外小鼠皮层的光遗传工程小鼠体感神经元，根据压力水平实现刺激脉冲。这项工作代表了设计和使用大面积有机电子皮肤与神经集成的触摸反馈的替代肢体的一步。
Human skin relies on cutaneous receptors that output digital signals for tactile sensing in which the intensity of stimulation is converted to a series of voltage pulses. We present a power-efficient skin-inspired mechanoreceptor with a flexible organic transistor circuit that transduces pressure into digital frequency signals directly. The output frequency ranges between 0 and 200 hertz, with a sublinear response to increasing force stimuli that mimics slow-adapting skin mechanoreceptors. The output of the sensors was further used to stimulate optogenetically engineered mouse somatosensory neurons of mouse cortex in vitro, achieving stimulated pulses in accordance with pressure levels. This work represents a step toward the design and use of large-area organic electronic skins with neural-integrated touch feedback for replacement limbs.