The electrocardiogram of the Beagle dog: reference values and effect of sex, genetic strain, body position and heart rate
The electrocardiogram of the Beagle dog: reference values and effect of sex, genetic strain, body position and heart rate
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DOI：
10.1258/002367706776319088
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发表时间：
2006-04-01
影响因子：
2.4
通讯作者：
Rabernampianina, Y
中科院分区：
文献类型：
--
作者：
Hanton, G;Rabernampianina, Y
本研究的目的是建立用于毒理学研究的Beagle犬心电图参数数据库，并评估心电图（ECG）记录的供应商、性别、心率（HR）和体位对心电图参数的影响。记录了来自 Marshall Farms 的 934 只雌性和 946 只雄性狗以及来自 Harlan 的 27 只雌性和 30 只雄性狗的外周心电图导联，这些狗要么站在桌子上，要么被束缚在吊床上。测量 HR、RR、PQ 和 QT 间期、P 和 QRS 持续时间以及 P 波幅度。不同性别的心电图参数没有显着差异。与站在桌子上相比，当动物被限制在吊床上时，心脏轴向左移动。哈伦犬的 PQ 间隔高于马歇尔犬（约 9%）。 HR 与 QT 呈负相关（线性相关系数：r = -0.61 至 -0.74），这强调了在解释 QT 间期变化时需要针对 HR 校正 QT 间期的公式。 HR 还与 PQ 间期呈负相关（r = -0.26 至 -0.11），而 HR 与 P 波幅度之间呈正相关（r = 0.21-0.34）。通过计算 10 秒内测量的最大 RR 间期与最小 RR 间期的比率来量化呼吸性窦性心律失常 (SA) 的水平。该比率与 HR 呈负相关（r = -0.49 至 -0.33）。因此，在高 HR 时，SA 不如低 HR 时那么明显，但它并没有完全消失。逐搏变化分析表明，QT、PQ 间期以及 P 波振幅随时间波动，且波动程度与 SA 水平呈正相关。总之，我们已经为某些心电图参数的持续时间和/或幅度在记录期间的平均值和变异性方面建立了参考值，并且我们评估了身体位置、遗传应变和心率对心电图参数的影响。这些数据可以用作解释比格犬心电图的基线。
The aim of the study was to establish a database for electrocardiographic parameters of Beagle dogs used for toxicological studies and to evaluate the influence of supplier, sex, heart rate (HR) and body position for electrocardiogram (ECG) recording on ECG parameters. Peripheral ECG leads were recorded from 934 female and 946 male dogs from Marshall Farms and 27 females and 30 males from Harlan, either standing on a table or restrained in a hammock. HR, RR, PQ and QT intervals, P and QRS duration and P-wave amplitude were measured. There were no major differences between sexes for ECG parameters. The axis of the heart was shifted to the left when the animals were restrained in a hammock compared to when they were standing on a table. The PQ interval was higher (about 9%) in Harlan than in Marshall dogs. HR was negatively correlated with QT (coefficient of linear correlation: r = -0.61 to -0.74), which emphasizes the need for a formula correcting QT interval for HR when interpreting changes in QT interval. HR was also negatively correlated with PQ intervals (r = -0.26 to -0.11), whereas a positive correlation was found between HR and the amplitude of the P wave (r = 0.21-0.34). The level of the respiratory sinus arrhythmia (SA) was quantified by calculating the ratio of maximum to minimum RR interval measured over a 10 s period. This ratio was negatively correlated with HR (r = -0.49 to -0.33). Therefore, at high HRs, SA was less marked than at low HRs, but it did not completely disappear. Analysis of beat-to-beat variation indicated that QT and PQ intervals and the amplitude of P wave fluctuated over time and the degree of this variability was positively correlated with the level of SA. in conclusion, we have established reference values for the duration and/or amplitude of some ECG parameters both in terms of means and variability over the recording period, and we have evaluated the influence of body position, genetic strain and HR on the ECG parameters. These data can be used as baseline for the interpretation of the ECG of Beagle dogs.