CNS-MANIFESTATIONS OF EPIDEMIC HEMORRHAGIC-FEVER - AN ADVANCED MANIFESTATION OF DISEASE ASSOCIATED WITH POOR PROGNOSIS
CNS-MANIFESTATIONS OF EPIDEMIC HEMORRHAGIC-FEVER - AN ADVANCED MANIFESTATION OF DISEASE ASSOCIATED WITH POOR PROGNOSIS
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DOI：
10.1001/archinte.143.11.2070
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
GE, HC
中科院分区：
文献类型：
--
作者：
COHEN, MS;KWEI, HE;GE, HC
对134例临床诊断为流行性出血热（EHF）的病例进行了回顾性分析。根据出血性并发症和蛋白尿、BP [血压]异常和发热的程度，74例患者的疾病可归类为严重。在这些患者中，46例有一种或多种CNS异常。常见的临床表现包括意识模糊、脑膜痉挛和抽搐。发热异常与中枢神经系统异常无关，而血压紊乱、酸中毒和氮质血症在中枢神经系统疾病患者中明显更常见。在本研究中，14%的患者死亡，所有患者均患有CNS障碍; CNS障碍患者的死亡率为41%。显然，EHF的中枢神经系统表现是多因素引起的，它们确定了一个疾病晚期和严重预后的患者子集。
The records of 134 patients with the clinical diagnosis of epidemic hemorrhagic fever (EHF) were evaluated. The conditions or 74 patients could be categorized as serious based on hemorrhagic complications and magnitude of proteinuria, BP [blood pressure] abnormality and pyrexia. Of these patients 46 had one or more CNS abnormalities. Common manifestations included confusion, meningismus and convulsions. Whereas abnormality in fever could not be related to CNS abnormality, BP disturbance, acidosis and azotemia were significantly more common among patients with CNS disease. Of the patients in this study 14% died, and all of them had CNS disturbance; mortality among patients with CNS disturbance was 41%. Evidently, the CNS manifestations of EHF are multifactorial in cause and they identify a subset of patients with an advanced stage of disease and a grave prognosis.