Individual chronic mountain sickness symptom is an early warning sign of cognitive impairment
Individual chronic mountain sickness symptom is an early warning sign of cognitive impairment
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个体慢性高山病症状是认知障碍的早期预警信号
DOI：
10.1016/j.physbeh.2019.112748
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发表时间：
2020-02-01
影响因子：
2.9
通讯作者：
Li Peng
中科院分区：
文献类型：
--
作者：
Zheng Shanjun;Xie Shenwei;Li Peng
目的：探讨慢性高原病（CMS）各种症状与认知表现的关系，并确定个体CMS症状是否可作为长期高原迁徙者特异性认知功能障碍的预警信号。方法：对生活在海拔3850米1 ~ 5年的287名工人进行研究。根据《国际青海CMS诊断标准》，采用问卷调查法测定7种CMS自觉性症状的存在及严重程度，同时测定血液中血红蛋白（Hb）水平。然后进行六项神经行为测试来评估认知功能，并测量生理指标，包括匹兹堡睡眠质量指数（PSQI）和动脉氧饱和度。结果：与CMS各症状的0分相比，1-3分普遍对应于某些认知方面的损害。此外，相关分析显示，不同CMS症状的受试者表现出特定的认知障碍。紫绀患者的听觉和视觉反应较慢，运动敏捷性下降，视觉记忆能力差（R = = 0.236, 0.261, 0.155, 0.221, P < 0.01）。睡眠障碍、红细胞过多与记忆能力差显著相关（R = = 0.206 ~ 0.251, P < 0.01），头痛症状与运动敏捷性受损主要相关（R = =0.266, P < 0.01）。血红蛋白>= 200 g/L, SpO(2) = 7分别对应红细胞增多、发绀和睡眠障碍症状，预示认知功能下降。结论：青海CMS评分系统中使用的症状特征与长期高原迁移者的特定认知障碍相关，这支持了使用CMS相关症状监测高海拔CMS患者和非CMS人群认知状态的有效性。
Objective: : To investigate the relationship between various chronic mountain sickness (CMS) symptoms and cognitive performances and identify whether individual CMS symptom can be used as early warning signs of specific cognitive impairment in long-term high altitude migrators.Methods: : A total of 287 workers living at an altitude of 3850 m for 1-5 years participated in the study. According to the International Qinghai CMS Diagnostic Criteria, a questionnaire survey was conducted to measure the existence and severity of 7 self-perceptible CMS symptoms in addition to hemoglobin (Hb) levels in the blood. Six neurobehavioral tests were then conducted to assess cognitive function, and physiological indices, including Pittsburgh Sleep Quality Index (PSQI) and arterial oxygen saturation were also measured.Results: : Compared with a score of 0 for each CMS symptom, scores of 1-3 universally corresponded to impairment in some aspects of cognition. Moreover, the correlation analysis revealed that subjects with different CMS symptoms exhibited specific aspects of cognitive impairment. Cyanosis was associated with slower auditory and visual reactions, reduced motion agility and poor visual memory ability (R = = 0.236, 0.261, 0.155, 0.221, P < 0.01). Sleep disturbance and excessive erythrocytosis were significantly correlated to poor memory ability (R = = 0.206-0.251, P < 0.01), and the symptoms of headache were mainly associated with impaired motion agility (R = =0.266, P < 0.01). The results also indicated that Hb >= 200 g/L, SpO(2) = 7, which correspond to excessive erythrocytosis, cyanosis and sleep disturbance symptoms respectively, predicted the decline of cognitive function.Conclusions: : The characteristics of symptoms used in Qinghai CMS Score System were associated with specific cognitive impairments in long-term plateau migrators, which supported the usefulness of monitoring cognitive status using CMS-related symptoms for both CMS patients and non-CMS people at high altitude.