Water-related nosocomial pneumonia caused by Legionella pneumophila serogroups 1 and 10.
Water-related nosocomial pneumonia caused by Legionella pneumophila serogroups 1 and 10.
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由嗜肺军团菌血清型 1 和 10 引起的与水相关的医院肺炎。
DOI：
10.1093/infdis/152.2.356
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
R. V. Furth
中科院分区：
文献类型：
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作者：
Pieter L. Meenhorst;A. L. Reingold;Dirk G. Groothuis;G. W. Gorman;Hazel W. Wilkinson;Roger M. McKINNEY;James C. Feeley;Don J. Brenner;R. V. Furth
在1978年8月至1983年11月期间，莱顿大学医院发生了21例嗜肺军团菌肺炎病例，主要是免疫功能低下的患者。从4名患者的支气管分泌物中分离到一个新的嗜肺乳杆菌血清组，命名为10号血清组(原型菌株Leiden 1)，5名患者有感染该细菌的血清学证据。有9名患者感染了经培养确认的嗜肺乳杆菌血清群1。从大楼的热水供应中也分离到了嗜肺乳杆菌血清群1和10，21名患者中已有19人住进了这两个群。从患者和热水中分离到的嗜肺性乳杆菌分离株在单抗研究中是相同的，并且具有相同的质粒谱。这些发现进一步证明，在我们医院，受嗜肺杆菌污染的饮用水是感染源之一，主要是在免疫功能低下的患者中。
Between August 1978 and November 1983, 21 cases of pneumonia caused by Legionella pneumophila occurred in the Leiden University Hospital, mainly among immunocompromised patients. A new serogroup of L. pneumophila, designated serogroup 10 (prototype strain Leiden 1), was isolated from bronchial secretions of four patients, and five patients had serological evidence of infection with this organism. Nine patients had a culture-confirmed infection with L. pneumophila serogroup 1. L. pneumophila serogroups 1 and 10 were also isolated from the hot potable water supply in the building to which 19 of the 21 patients had been admitted. The isolates of L. pneumophila serogroup 1 from patients and the hot potable water were identical in studies with monoclonal antibodies and had the same plasmid profiles. These findings provide further evidence that in our hospital potable water contaminated with L. pneumophila is a source of infection, mainly in immunocompromised patients.