Cell-cycle properties and proliferation kinetics of late erythroid progenitors in murine bone marrow.
Cell-cycle properties and proliferation kinetics of late erythroid progenitors in murine bone marrow.
复制标题
小鼠骨髓中晚期红系祖细胞的细胞周期特性和增殖动力学。
DOI：
10.1182/blood.v60.2.519.519
复制
发表时间：
1980
影响因子：
2.6
通讯作者：
R. Zelick
中科院分区：
文献类型：
--
作者：
F. Monette;R. Kent;E. Weiner;R. F. Jarris;P. L. Ouellette;J. Thorson;R. Zelick
骨髓CFUE的细胞周期特性进行了评估，在正常的再生细胞制剂。此外，CFUE的促红细胞生成素敏感性与这些细胞的细胞周期分布相关。结果表明，促红细胞生成素敏感性与CFUE细胞周期的S期偶联，G2/M/G1期的CFUE对激素的敏感性低2至10倍。它的结论是CFUE细胞周期本身不是一个焦点红细胞生成调节。
The cell-cycle properties of marrow CFUE were assessed in normal regenerating cell preparations. In addition, the erythropoietin sensitivity of CFUE was correlated to the cell-cycle distribution of these cells. The results suggest a coupling of erythropoietin sensitivity to the S-phase of the CFUE cell cycle in so far as CFUE in G2/M/G1 were 2 to 10 times less sensitive to the hormone. It is concluded that the CFUE cell cycle per se is not a focus for erythropoietic regulation.