Predictive value of gadolinium enhancement in differentiating ALT/WD liposarcomas from benign fatty tumors
Predictive value of gadolinium enhancement in differentiating ALT/WD liposarcomas from benign fatty tumors
复制标题
DOI：
10.1007/s00256-004-0884-5
复制
发表时间：
2005-05-01
影响因子：
2.1
通讯作者：
Damron, TA
中科院分区：
文献类型：
--
作者：
Panzarella, MJ;Naqvi, AH;Damron, TA
目的：确定 MRI 钆增强在区分非典型脂肪瘤（ALT）/高分化（WD）脂肪肉瘤与良性脂肪瘤中的预测价值。设计：对所有经术前钆增强 MRI 证实的脂肪瘤进行组织学检查。仅包括那些主要具有脂肪信号的肿瘤。计算了钆增强和活检作为 ALT/WD 脂肪肉瘤最终诊断预测因子的敏感性、特异性以及阳性和阴性预测值。患者：从 1994 年至 2002 年间评估脂肪瘤的 129 名患者中，通过术前钆增强 MRI 将患者群体缩小到 32 例切除的脂肪瘤。结果：作为 ALT/WD 脂肪肉瘤的预测因子，钆增强的存在显示出 100% 的敏感性、71% 的特异性、53% 的阳性预测值和 100% 的阴性预测值。针刺或切开活检对 ALT/WD 脂肪肉瘤的诊断具有 57% 的敏感性、100% 的特异性、100% 的阳性预测值和 63% 的阴性预测值。结论：同质脂肪软组织肿瘤的钆增强是确定 ALT/WD 脂肪肉瘤可能诊断的敏感筛查工具。另一方面，活检具有特异性但不敏感。
Objective: To determine the predictive value of gadolinium enhancement on MRI in differentiating atypical lipomatous tumor (ALT)/ well-differentiated (WD) liposarcoma from benign fatty tumors. Design: All histologically proven fatty tumors with preoperative gadolinium-enhanced MRI were reviewed. Only those tumors with predominantly fatty signal were included. Sensitivity, specificity, and positive and negative predictive values for both gadolinium enhancement and biopsy as predictors for the final diagnosis of ALT/WD liposarcoma were calculated. Patients: From 129 patients evaluated for fatty tumors between 1994 and 2002, the patient population was narrowed to 32 excised fatty tumors with preoperative gadolinium-enhanced MRI. Results: As a predictor of ALT/WD liposarcoma, the presence of gadolinium enhancement showed 100% sensitivity, 71% specificity, 53% positive predictive value and 100% negative predictive value. Needle or incisional biopsy yielded 57% sensitivity, 100% specificity, 100% positive predictive value and 63% negative predictive value for a diagnosis of ALT/WD liposarcoma. Conclusions: Gadolinium enhancement of a homogeneous fatty soft tissue tumor is a sensitive screening tool to determine possible diagnosis of ALT/WD liposarcoma. Biopsy, on the other hand, is specific but insensitive.