Distinct distribution of killer-cell immunoglobulin-like receptor genes in the Mugil and Ilaita areas of Papua New Guinea.
Distinct distribution of killer-cell immunoglobulin-like receptor genes in the Mugil and Ilaita areas of Papua New Guinea.
复制标题
巴布亚新几内亚穆吉尔和伊莱塔地区杀伤细胞免疫球蛋白样受体基因的独特分布。
DOI：
10.1111/j.1399-0039.2012.01848.x
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Witt,CS
中科院分区：
文献类型：
--
作者：
John,E;Christiansen,FT;Mueller,I;Schofield,L;Senitzer,D;Siba,P;Witt,CS
研究了巴布亚新几内亚沿海（Mugil社区）和内陆（Ilaita社区）社区杀伤细胞免疫球蛋白样受体（KIR）基因和KIR 2 DL 4跨膜等位基因的频率。KIR基因之间的连锁不平衡和等位基因之间的KIR 2 DL 4和theKIR基因是类似的，在其他人群中发现的通常的基因顺序在巴布亚新几内亚单倍型的保护。尽管两个种群相距仅300 km，但KIR基因的频率在两个种群之间存在显著差异。我们鉴定了一些缺乏KIR2DL4基因的个体和一些在外显子6的多聚腺嘌呤区有11个腺嘌呤的KIR2DL4等位基因的个体。一个相对较低的频率KIR A单倍型被发现在这两个群体，特别是在内陆社区。theKIR基因频率是一致的内陆Ilaita社区密切相关的澳大利亚土著人和南部印第安人，而theKIR基因频率的沿海Mugil社区似乎已经受到影响，无论是最近或古老的混合物从人口具有较高的频率KIR单倍型。
The frequency of the killer‐cell immunoglobulin‐like receptor (KIR) genes and transmembrane alleles ofKIR2DL4were studied in coastal (Mugil community) and inland (Ilaita community) communities in Papua New Guinea. Linkage disequilibria betweenKIRgenes and between alleles ofKIR2DL4and theKIRgenes were similar to those found in other populations suggesting conservation of the usual gene order in Papua New Guinean haplotypes. Significant differences in the frequency ofKIRgenes were found between the two populations despite being separated by only 300 km. Examples of individuals who lacked theKIR2DL4gene and others whoseKIR2DL4allele appeared to have 11 adenines in the polyadenine tract in exon 6 were identified. A relatively low frequency of the KIR A haplotype was found in both populations and particularly in the inland community. TheKIRgene frequencies were consistent with the inland Ilaita community being closely related to Australian Aborigines and southern Indians, whereas theKIRgene frequencies of the coastal Mugil community appeared to have been influenced either by recent or ancient admixture from populations with a higher frequency of the KIR A haplotype.