Dynamic Changes of the Infralimbic Cortex and Its Regulation of the Prelimbic Cortex in Rats with Chronic Inflammatory Pain
Dynamic Changes of the Infralimbic Cortex and Its Regulation of the Prelimbic Cortex in Rats with Chronic Inflammatory Pain
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DOI：
10.1007/s12264-023-01159-x
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发表时间：
2024-01-05
影响因子：
5.6
通讯作者：
Wan，You
中科院分区：
文献类型：
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作者：
Ma，Longyu;Yue，Lupeng;Wan，You
前边缘皮层（PL）积极参与疼痛调制。边缘下皮层（infraalimbic cortex，IL）对PL有调节作用。然而，这种调节如何影响疼痛仍不清楚。在本研究中，我们记录了PL锥体神经元对伤害性刺激的暂时性过度活动，但在体电生理记录的IL功能暂时性低下。操作PL或IL对热痛觉过敏有相反的作用。此外，功能连接和化学调控的亚区之间的IL对PL的抑制作用。从IL到PL的通路的激活减轻了热痛觉过敏，而其抑制加剧了慢性疼痛。总的来说，我们的研究结果表明，内侧前额叶皮层在慢性疼痛中的作用的一个新的机制：IL的功能减退导致PL的过度活跃，从而调节热痛觉过敏，从而有助于慢性疼痛。
The prelimbic cortex (PL) is actively engaged in pain modulation. The infralimbic cortex (IL) has been reported to regulate the PL. However, how this regulation affects pain remains unclear. In the present study, we recorded temporary hyper-activity of PL pyramidal neurons responding to nociceptive stimuli, but a temporary hypo-function of the IL byin vivoelectrophysiological recording in rats with peripheral inflammation. Manipulation of the PL or IL had opposite effects on thermal hyperalgesia. Furthermore, the functional connectivity and chemogenetic regulation between the subregions indicated an inhibitory influence of the IL on the PL. Activation of the pathway from the IL to the PL alleviated thermal hyperalgesia, whereas its inhibition exacerbated chronic pain. Overall, our results suggest a new mechanism underlying the role of the medial prefrontal cortex in chronic pain: hypo-function of the IL leads to hyperactivity of the PL, which regulates thermal hyperalgesia, and thus contributes to the chronicity of pain.