INHALATION OF BENZPYRENE AND CANCER IN MAN
INHALATION OF BENZPYRENE AND CANCER IN MAN
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DOI：
10.1111/j.1749-6632.1976.tb23100.x
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发表时间：
1976-01-01
影响因子：
5.2
通讯作者：
SEIDMAN, H
中科院分区：
文献类型：
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作者：
HAMMOND, EC;SELIKOFF, IJ;SEIDMAN, H
香烟烟雾和受污染的城市空气都含有极少量的苯并（a）芘或BaP，如果以皮肤涂抹或皮下注射等方式使用相对大量的BaP，这种物质会对实验动物致癌。这表明香烟烟雾中的BaP可能是吸烟与肺癌之间高度相关的原因，也表明城市空气中的BaP污染可能会增加肺癌的风险。Wy-nder和霍夫曼发现，在100支美国机械吸烟的香烟中，平均有2.5微克的苯并[a]芘。基于这一点，似乎即使在一生中大量吸烟的情况下，与小鼠产生皮肤癌所需的剂量相比，每平方厘米支气管组织中可能扩散的BaP浓度也非常小。
Both cigarette smoke and polluted urban air contain very small amounts of benzo (a) pyrene, or BaP, a substance which is carcinogenic to experimental animals if relatively large amounts are applied in certain ways such as skin painting or subcutaneous injection. This suggested the possibility that the BaP in cigarette smoke might account for the high degree of association between cigarette smoking and lung cancer; and it suggested the possibility that BaP pollution of urban air might perhaps increase the risk of lung cancer. Wy-nder and Hoffman found an average of 2.5 micrograms of BaP in the smoke from 100 American cigarettes smoked mechanically. Based upon this, it would appear that• even durinE; a lifetime of heavy cigarette smoking, the concentration of BaP per square centimeter of bronchial tissue over which it might be spread would be extremely small as compared with the dose required to produce skin cancer in mice.