Meditation and Music Improve Memory and Cognitive Function in Adults with Subjective Cognitive Decline: A Pilot Randomized Controlled Trial.
Meditation and Music Improve Memory and Cognitive Function in Adults with Subjective Cognitive Decline: A Pilot Randomized Controlled Trial.
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DOI：
10.3233/jad-160867
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Kandati S
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文献类型：
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作者：
Innes KE;Selfe TK;Khalsa DS;Kandati S
虽然预防或减缓高危人群认知能力下降的有效疗法仍然难以捉摸，但有证据表明，身心干预可能有希望。在这项研究中，我们评估了Kirtan Kriya冥想（KK）和听音乐（ML）对经历主观认知下降（SCD）的成年人认知结果的影响，SCD是阿尔茨海默病的一个强有力的预测因素。60名患有SCD的参与者被随机分配到KK或ML计划，并要求他们每天练习12分钟，持续3个月，然后在接下来的3个月内自行决定。在基线、3个月和6个月时，我们测量了记忆和认知功能[记忆功能问卷（MFQ）、线索制作测试（TMT-A/B）和数字符号替代测试（DSST）]。这项为期6个月的研究由53名参与者（88%）完成。参与者在前3个月平均进行了93%（91% KK，94% ML）的课程，在3个月的实践可选随访期间，平均进行了71%（68% KK，74% ML）的课程。两组在3个月时的记忆和认知表现（MFQ、DSST、TMT-A/B; p ≤ 0.04）均显示出显著改善。6个月时，总体增益保持或改善（p ≤ 0.006），效应量范围从中等（DSST，ML组）到大（DSST，KK组; TMT-A/B，MFQ）。这些变化与治疗预期无关，也不因年龄、性别、基线认知评分或其他因素而存在差异。这项初步随机对照试验的结果表明，冥想或ML的练习可以显着增强SCD成人的主观记忆功能和客观认知表现，并可能为改善这一人群的结局提供希望。
While effective therapies for preventing or slowing cognitive decline in at-risk populations remain elusive, evidence suggests mind-body interventions may hold promise. In this study, we assessed the effects of Kirtan Kriya meditation (KK) and music listening (ML) on cognitive outcomes in adults experiencing subjective cognitive decline (SCD), a strong predictor of Alzheimer’s disease. Sixty participants with SCD were randomized to a KK or ML program and asked to practice 12 minutes/day for 3 months, then at their discretion for the ensuing 3 months. At baseline, 3 months, and 6 months we measured memory and cognitive functioning [Memory Functioning Questionnaire (MFQ), Trail-making Test (TMT-A/B), and Digit-Symbol Substitution Test (DSST)]. The 6-month study was completed by 53 participants (88%). Participants performed an average of 93% (91% KK, 94% ML) of sessions in the first 3 months, and 71% (68% KK, 74% ML) during the 3-month, practice-optional, follow-up period. Both groups showed marked and significant improvements at 3 months in memory and cognitive performance (MFQ, DSST, TMT-A/B; p’s ≤ 0.04). At 6 months, overall gains were maintained or improved (p’s ≤ 0.006), with effect sizes ranging from medium (DSST, ML group) to large (DSST, KK group; TMT-A/B, MFQ). Changes were unrelated to treatment expectancies and did not differ by age, gender, baseline cognition scores, or other factors. Findings of this preliminary randomized controlled trial suggest practice of meditation or ML can significantly enhance both subjective memory function and objective cognitive performance in adults with SCD, and may offer promise for improving outcomes in this population.