Alterations of serum brain-derived neurotrophic factor levels in early alcohol withdrawal
Alterations of serum brain-derived neurotrophic factor levels in early alcohol withdrawal
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DOI：
10.1093/alcalc/agm172
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发表时间：
2008-05-01
影响因子：
2.8
通讯作者：
Leu, Sy-Jye
中科院分区：
文献类型：
--
作者：
Huang, Ming-Chyi;Chen, Chun-Hsin;Leu, Sy-Jye
目的：酒精戒断增强的神经毒性有助于成瘾过程。脑源性神经营养因子（BDNF）在神经元可塑性和学习过程中起重要作用。本研究探讨了酒精中毒患者基线时和戒酒一周后血清BDNF水平的变化。方法：25例酒精中毒患者接受酒精戒断治疗，22例健康对照者接受酒精戒断治疗。分别于戒酒后第1天和第7天采集患者血清，采用双抗体夹心酶联免疫吸附法测定血清BDNF水平。通过临床研究所戒断评估-酒精，每8小时修订一次，评价戒断症状的严重程度。结果：酒精中毒患者和对照组血清BDNF水平无显著差异。但在戒酒一周后，BDNF水平显著增加（从13.9 +/- 3.8 ng/ml增加到15.4 +/- 3.8 ng/ml，P = 0.03）。基线BDNF水平与基线戒断严重程度呈显著正相关（r = 0.45，P = 0.03）。结论：本研究提示，早期酒精戒断时血清BDNF水平升高，提示BDNF可能参与了酒精戒断过程中的神经适应。
Aims: Alcohol withdrawal-enhanced neurotoxicity contributes to the addictive process. Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal plasticity and learning. In this study, we explored the changes of serum BDNF levels in alcoholic patients at baseline and after one-week alcohol withdrawal. Methods: Twenty-five alcoholic patients were admitted for alcohol detoxification treatment, and 22 healthy control subjects were also enrolled. We collected blood samples of the patient group on the first and seventh day of alcohol withdrawal, and measured serum BDNF level with sandwich enzyme-linked immunosorbent assay. The severity of withdrawal symptoms was evaluated by the Clinical Institute Withdrawal Assessment-Alcohol, Revised every eight hours. Results: Serum BDNF levels did not differ significantly between alcoholic patients and control subjects. But BDNF levels were found to be significantly increased one week after alcohol withdrawal (from 13.9 +/- 3.8 ng/ml to 15.4 +/- 3.8 ng/ml, P = 0.03). A significant positive correlation was found between baseline BDNF level and baseline withdrawal severity (r = 0.45, P = 0.03). Conclusions: The present study suggests that elevated serum BDNF levels were found in early alcohol withdrawal, implying that BDNF may involve in neuroadaptation during the period.