Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts
Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts
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DOI：
10.1021/jf073065v
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发表时间：
2008-03-26
影响因子：
6.1
通讯作者：
Wang, Mingfu
中科院分区：
文献类型：
--
作者：
Peng, Xiaofang;Cheng, Ka-Wing;Wang, Mingfu
据报道，肉桂皮通过其抗氧化剂和胰岛素增强活性有效缓解糖尿病。在这项研究中，肉桂对晚期糖基化终产物（AGEs）的形成抑制作用在牛血清白蛋白（BSA）-葡萄糖模型进行了研究。几种酚类化合物，如儿茶素，表儿茶素，和原花青素B2，和酚聚合物被确定从水肉桂提取物的亚馏分。这些化合物对AGEs的形成有明显的抑制作用。它们的抗糖基化活性不仅与其抗氧化活性有关，还与它们对AGE形成的中间反应性羰基如甲基乙二醛（MGO）的捕获能力有关。对MGO与原花青素B-2反应的初步研究表明，MGO-原花青素B-2加合物为初级产物，推测为立体异构体。这是首次报道原花青素能有效地抑制活性羰基，从而抑制AGEs的形成。由于原花青素的行为方式与临床试验中探索的第一种AGE抑制剂氨基胍（AG）相似，因此它们显示出作为缓解糖尿病并发症的药物开发的巨大潜力。
Cinnamon bark has been reported to be effective in the alleviation of diabetes through its antioxiclant and insulin-potentiating activities. In this study, the inhibitory effect of cinnamon bark on the formation of advanced glycation endproducts (AGEs) was investigated in a bovine serum albumin (BSA)-glucose model. Several phenolic compounds, such as catechin, epicatechin, and procyaniclin B2, and phenol polymers were identified from the subfractions of aqueous cinnamon extract. These compounds showed significant inhibitory effects on the formation of AGEs. Their antiglycation activities were not only brought about by their antioxidant activities but also related to their trapping abilities of reactive carbonyl species such as methylglyoxal (MGO), an intermediate reactive carbonyl of AGE formation. Preliminary study on the reaction between MGO and procyaniclin B-2 revealed that MGO-procyanidin B-2 adducts are primary products which are supposed to be Stereoisomers. This is the first report that proanthocyaniclins can effectively scavenge reactive carbonyl species and thus inhibit the formation of AGEs. As proanthocyaniclins behave in a similar fashion as a.minoguanicline (AG), the first AGE inhibitor explored in clinical trials, they show great potential to be developed as agents to alleviate diabetic complications.