Chronic suppression in mice with anti-IgD: role of B-cell numbers.
Chronic suppression in mice with anti-IgD: role of B-cell numbers.
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抗 IgD 小鼠的慢性抑制：B 细胞数量的作用。
DOI：
10.1111/j.1749-6632.1982.tb25689.x
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发表时间：
1982
影响因子：
5.2
通讯作者：
Thorbecke,GJ
中科院分区：
文献类型：
--
作者：
Baine,Y;Chen,YW;Jacobson,EB;Pernis,B;Siskind,GW;Thorbecke,GJ
早期对小鼠的研究表明，小鼠的免疫功能存在某些缺陷，然而，在最近的两项研究中，没有检测到对脾中抗体产生的有害影响。尽管没有可检测到的IGD‘B细胞和Ig’细胞的数量显著减少。由于脾含有在淋巴结中缺乏的IgM‘IgD-B细胞群，5抗-IGD治疗可能比脾更严重地耗尽淋巴结的B细胞室。因此，本研究比较了从出生起就用抗-IGD慢性抑制对小鼠脾和淋巴结免疫反应的影响。此外，还研究了抗-IgD处理小鼠脾B细胞传递免疫应答的能力。
Early studies on mice treated with anti-IgD from birth have suggested the presence of certain deficiencies in their immune However, no detrimental effects on antibody production in the spleen were detected in two recent studies3.'in spite of the absence of detectable IgD'B-cells and markedly reduced number of Ig'cells. Since the spleen contains an IgM'IgD-B-cell population which is lacking in the lymph node, 5 it is possible that anti-IgD treatment more severely depletes the B-cell compartment of the lymph node than of the spleen. Therefore, in the present study a comparison was made of the effect of chronic suppression with anti-IgD from birth on the immune response in the spleen and lymph nodes. In addition, the ability of splenic B-cells from anti-IgD treated mice to transfer an immunologic response was studied.