Diagnostic accuracy of cadmium-zinc-telluride-based myocardial perfusion SPECT: impact of attenuation correction using a co-registered external computed tomography
Diagnostic accuracy of cadmium-zinc-telluride-based myocardial perfusion SPECT: impact of attenuation correction using a co-registered external computed tomography
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DOI：
10.1093/ehjci/jev312
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发表时间：
2016-09-01
影响因子：
6.2
通讯作者：
Bengel, Frank M.
中科院分区：
文献类型：
--
作者：
Caobelli, Federico;Akin, Muharrem;Bengel, Frank M.
引言基于计算机断层扫描（CT）的衰减校正（AC）提高了标准心肌灌注SPECT的准确性。大多数专用碲锌镉（CZT）SPECT摄像机未配备集成CT组件。我们的目的是确定AC的影响，CZT SPECT的诊断性能，使用共同注册与外部低剂量CT.Methods六十例患者进行CZT SPECT（GE发现530 C）与Tc-99 m-sestamibi在休息和regadenoson应力。使用商业软件，将SPECT图像与在单独系统（GE Discovery 670 NMCT）上采集的低剂量CT共配准。使用迭代算法重建衰减校正和非校正（NC）图像。在44例6个月内接受有创血管造影术的患者中测量了准确性。在其余16名测试前可能性较低的患者中进行了正常性比较（
Introduction Computed tomography (CT)-based attenuation correction (AC) improves the accuracy of standard myocardial perfusion SPECT. Most dedicated cadmium-zinc-telluride (CZT) SPECT cameras are not equipped with an integrated CT component. We aimed to determine the impact of AC on diagnostic performance of CZT SPECT using co-registration with an external low-dose CT.Methods Sixty patients underwent CZT SPECT (GE Discovery 530c) with Tc-99m-sestamibi at rest and following regadenoson stress. Using commercial software, SPECT images were co-registered with a low-dose CT acquired on a separate system (GE Discovery 670NMCT). Attenuation corrected and non-corrected (NC) images were reconstructed using an iterative algorithm. Accuracy was measured in 44 patients who had undergone invasive angiography within 6 months. Normalcy was compared in the remaining 16 patients who had a low pre-test likelihood (