Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in pa with acute coronary syndrome
Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in pa with acute coronary syndrome
复制标题
DOI：
10.1067/mhj.2001.112238
复制
发表时间：
2001-02-01
影响因子：
4.8
通讯作者：
Okumura, K
中科院分区：
文献类型：
--
作者：
Inokubo, Y;Hanada, H;Okumura, K
背景先前对急性冠脉综合征（ACS）患者动脉粥样硬化切除术标本的研究暗示了蛋白水解酶的作用。我们检测了ACS患者冠状动脉循环中基质金属蛋白酶-9 （MMP-9）和金属蛋白酶-1组织抑制剂（TIMP-1）血浆水平是否升高。方法与结果29例ACS患者（急性心肌梗死组20例[1组]，不稳定型心绞痛组9例[21组]，稳定型心绞痛组17例（3组），对照组20例（4组））血浆MMP-9和TIMP-1水平（毫微克/毫升）。组1为左前降支闭塞，组2、组3为左前降支罪魁祸首病变。第一组患者在发病后12小时内直接行冠状动脉成形术时采集血样。4组间MMP-9和TIMP-1的Ao水平均无差异。与4组相比，2组和2组的MMP-9和TIMP-1的GCV-Ao差异均显著增加。在第3组和第4组之间没有任何不同。GCV-Ao组MMP-9和TIMP-1水平的差异与1组最大肌酸激酶水平无关。结论ACS患者冠脉循环中血浆MMP-9和TIMP-1水平升高，提示ACS患者有血小板主动破裂的过程。
Background Previous studies on atherectomy specimens from patients with acute coronary syndrome (ACS) implicated the role of proteolytic enzymes. We examined whether the plasma levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were increased in the coronary circulation in ACS.Methods and Results The plasma levels (nanograms per milliliter) of MMP-9 and TIMP-1 in the aorta (Ao) and great cardiac vein (GCV) were measured in 29 patients with ACS (20 with acute myocardial infarction [group 1] and 9 with unstable angina [group 21), 17 with stable effort angina (group 3), and 20 control subjects (group 4). Group 1 patients had occlusion in the left anterior descending artery (LAD), and groups 2 and 3 patients had culprit lesion in the LAD. In group 1 blood samples were obtained at the time of direct coronary angioplasty done within 12 hours after the onset. The Ao level of either MMP-9 or TIMP-1 did not differ among the 4 groups. The GCV-Ao differences in MMP-9 and TIMP-1 were both significantly increased in groups and 2 compared with those in group 4. Neither of them was different between groups 3 and 4. Neither the GCV-Ao difference in MMP-9 or TIMP-1 level was correlated with the maximal creatine kinase level in group 1.Conclusions Increased plasma levels of MMP-9 and TIMP-1 were detected in the coronary circulation in ACS patients, suggesting a process of active plaque rupture in ACS.