An Accurate Substitution Method To Minimize Left Censoring Bias in Serum Steroid Measurements
An Accurate Substitution Method To Minimize Left Censoring Bias in Serum Steroid Measurements
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DOI：
10.1210/en.2019-00340
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发表时间：
2019-10-01
期刊：
影响因子：
4.8
通讯作者：
Ly, Lam P.
中科院分区：
文献类型：
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作者：
Handelsman, David J.;Ly, Lam P.
激素检测结果低于检测限 (DL) 可能会给定量分析带来偏差。尽管存在复杂的最大似然估计方法，但它们并没有被广泛使用，而简单的替代方法通常被临时使用，用数值替换不可检测的（UD）结果，以便于对完整数据集进行数据分析。然而，类固醇测量替代方法的偏差尚未报告。使用健康男性血清睾酮 (T)、DHT、雌二醇 (E2) 浓度的大型数据集 (n = 2896)，我们创建了修改后的数据集，其中 UD 样本比例不断增加 (
Hormone assay results below the assay detection limit (DL) can introduce bias into quantitative analysis. Although complex maximum likelihood estimation methods exist, they are not widely used, whereas simple substitution methods are often used ad hoc to replace the undetectable (UD) results with numeric values to facilitate data analysis with the full data set. However, the bias of substitution methods for steroid measurements is not reported. Using a large data set (n = 2896) of serum testosterone (T), DHT, estradiol (E2) concentrations from healthy men, we created modified data sets with increasing proportions of UD samples (