Mid-term predictive value of calciprotein particles in maintenance hemodialysis patients based on a gel -filtration assay
Mid-term predictive value of calciprotein particles in maintenance hemodialysis patients based on a gel -filtration assay
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DOI：
10.1016/j.atherosclerosis.2020.03.016
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发表时间：
2020-06-01
期刊：
影响因子：
5.3
通讯作者：
Kuro-o, Makoto
中科院分区：
文献类型：
--
作者：
Gatate, Yodo;Nakano, Shintaro;Kuro-o, Makoto
背景和目的：钙蛋白颗粒(CPPs)是一种含有胎球蛋白A结合的钙磷酸盐的纳米聚集体，与维持性血液透析患者的主动脉僵硬和冠状动脉钙化有关。一种新的凝胶过滤方法可以检测到低密度的小颗粒CPPs，这实际上是体内循环CPPs的主要形式。我们试图调查用凝胶过滤法测量循环CPP水平是否能准确预测维持性血液透析患者的硬终点。方法：本研究采用前瞻性、多中心、纵向、观察性设计。对108名参与这项研究的患者进行了约2年的随访。我们报告了全因死亡和心血管事件，其中包括主要的心脏、脑血管和肢体不良事件。结果：Kaplan-Meier分析显示，中位数较高的患者与中位数较低的患者之间无显著差异(P>0.05)。
Background and aims: Calciprotein particles (CPPs), nano-aggregates containing fetuin-A-bound calcium-phosphate, are associated with aortic stiffness and coronary calcification in maintenance hemodialysis patients. A novel gel-filtration assay can detect low-density small CPPs, which are actually a major form of circulating CPPs in vivo. We sought to investigate whether circulating CPP levels measured by gel-filtration method would accurately predict hard endpoints in maintenance hemodialysis patients. Methods: This study used a prospective, multicenter, longitudinal, and observational design. One-hundred eight patients enrolled in this study were followed-up for about 2 years. We reported all-cause death and cardiovascular events, which included major adverse cardiac, cerebrovascular, and limb events. Results: Kaplan-Meier analysis showed no significant difference between patients with the higher (>median) and lower (