Effects of hydrothermal treatment with CaCl2 solution on surface property and cell response of titanium implants
Effects of hydrothermal treatment with CaCl2 solution on surface property and cell response of titanium implants
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DOI：
10.1007/s10856-005-4753-0
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发表时间：
2005-11-01
影响因子：
3.7
通讯作者：
Ishikawa, K
中科院分区：
文献类型：
--
作者：
Nakagawa, M;Zhang, L;Ishikawa, K
为了使钛种植体植入人体后获得早期良好的骨结合，报道了使用NaOH或H2 O2等进行表面改性处理。在这项研究中，钛水热处理与氯化钙溶液在200摄氏度为24小时（氯化钙-HT）。扫描电子显微镜（SEM）观察清楚地表明，在模拟体液中浸泡的CaCl 2 HT处理的钛表面上的磷灰石沉积速度比其他化学处理的钛快。X射线光电子能谱（XPS）分析表明，CaCl 2水热处理后钛表面形成了Ti-O-Ca键。结果表明，已知对类骨磷灰石的形成起重要作用的TiO 2的厚度变得比抛光钛厚约3倍。抛光钛、NaOH、H_2O_2处理钛和CaCl_2处理钛上的初始附着MC_3T_3-E_1细胞数量几乎相同。培养5d后，MC 3 T3-E1细胞在CaCl 2-HT处理的钛板上的生长速度明显高于其他化学处理的钛板。采用10-20 mmol/L CaCl 2溶液在200 ℃下进行水热处理是制备具有良好生物活性和骨传导性的钛种植体的有效方法。(C)2005 Springer Science + Business Media，Inc.
In order to obtain early and good osteointegration after implantation of a titanium implant in the human body, the surface modified treatments using NaOH or H2O2 etc. were reported. In this study, titanium was hydrothermally treated with CaCl2 solutions at 200 degrees C for 24hr (CaCl2-HT). Scanning electron microscope (SEM) observation clearly showed apatite deposition on the surface of CaCl2 HT treated titanium faster than other chemical treated titanium immersion in simulated body fluid. X-ray photoelectron spectroscopy (XPS) analysis demonstrated that Ti-O-Ca bonding was formed on titanium surface by hydrothermal treatment with CaCl2 solution. And it was revealed that thickness of TiO2, which was known to play important roles for the formation of bone-like apatite, became approximately three times thicker than as-polished titanium. The amount of initial attached MC3T3-E1 cells on as-polished and NaOH, H2O2 and this CaCl2 HT treated titanium were almost the same values. After 5 days incubation, the growth rate of MC3T3-E1 cells on CaCl2-HT treated titanium was significantly higher than that on other chemical treated titanium. The hydrothermal treatment with 10-20 mmol/L CaCl2 solution at 200 degrees C was an effective method for the fabrication of titanium implant with good bioactivity and osteoconductivity. (C) 2005 Springer Science + Business Media, Inc.