Physical activity and ischemic stroke risk - The Atherosclerosis Risk in Communities Study
Physical activity and ischemic stroke risk - The Atherosclerosis Risk in Communities Study
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DOI：
10.1161/01.str.30.7.1333
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发表时间：
1999-07-01
期刊：
影响因子：
8.3
通讯作者：
Folsom, AR
中科院分区：
文献类型：
--
作者：
Evenson, KR;Rosamond, WD;Folsom, AR
背景和目的--根据1996年美国卫生局局长关于体力活动与健康的报告，体力活动与中风之间的关系尚不确定。因此，这项研究考察了14575名年龄在45岁至之间的社区研究参与者的动脉粥样硬化风险与缺血性中风风险的关系。方法通过持续的医院监测和队列研究参与者报告的住院情况，确定符合条件的潜在中风住院患者。所有的中风都通过住院记录进行了验证。使用贝克问卷将体力活动测量为运动、休闲(非运动)和工作。多变量Poisson和Cox比例风险模型被用来确定不同水平的体力活动与缺血性卒中发病率的关系。结果：在平均7.2年的随访中，189例发生了缺血性卒中。在运动、休闲和工作得分最低的四分位数中，缺血性中风的发病率最高。与调整了年龄、性别、种族中心、教育程度和吸烟因素后的活动最低四分位数相比，95%的CLS对缺血性中风的风险比为0.83(0.52，1.32)，休闲0.89(0.57，1.37)，工作0.69(0.47，1.00)。对体力活动和中风之间可能是中间变量(高血压、糖尿病、纤维蛋白原和体重指数)的因素进行进一步调整，可以减弱这种相关性。结论--我们的研究结果表明，在中年人中，体力活动与降低缺血性中风的风险之间存在微弱的相关性。这种关联可能是由于体力活动和其他风险因素之间的联系，也可能是由于偶然。
Background and Purpose-The relationship between physical activity and stroke is inconclusive according to the 1996 US Surgeon General's Report on Physical Activity and Health. Therefore, this study examined the relationship between physical activity and ischemic stroke risk among 14 575 Atherosclerosis Risk in Communities Study participants aged 45 to 64 years free of self-reported stroke and coronary heart disease at baseline.Methods-Eligible potential stroke hospitalizations were identified from ongoing hospital surveillance and from hospitalizations reported by the cohort study participants. All strokes were validated by hospitalization records. Physical activity was measured as sport, leisure (nonsport), and work with the use of the Baecke questionnaire. Multivariable Poisson and Cox proportional hazards models were used to determine the association of differing levels of physical activity with ischemic stroke incidence.Results-During an average of 7.2 years of follow-up, 189 incident ischemic strokes occurred. Ischemic stroke incidence rates were highest in the lowest quartile of sport, leisure, and work scores. The hazard rate ratios with 95% Cls for ischemic stroke for the highest quartile compared with the lowest quartile of activity adjusted for age, sex, race-center, education, and smoking, were sport 0.83 (0.52, 1.32), leisure 0.89 (0.57, 1.37), and work 0.69 (0.47, 1.00). Further adjustment for factors that likely were intermediate variables (hypertension, diabetes, fibrinogen, and body mass index) between physical activity and stroke attenuated the associations.Conclusions-Our findings suggest that physical activity was weakly associated with a reduced risk of ischemic stroke among middle-aged adults. The association may be due to links between physical activity and other risk factors or due to chance.