The effect of long-term unilateral deafness on the activation pattern in the auditory cortices of French-native speakers: influence of deafness side
The effect of long-term unilateral deafness on the activation pattern in the auditory cortices of French-native speakers: influence of deafness side
复制标题
DOI：
10.1186/1471-2202-10-23
复制
发表时间：
2009-03-23
期刊：
影响因子：
2.4
通讯作者：
Thai-Van, Hung
中科院分区：
文献类型：
--
作者：
Hanss, Julien;Veuillet, Evelyne;Thai-Van, Hung
背景资料：在听力正常的受试者中，单耳刺激在听觉皮层上产生了一种正常的模式，即对侧颞叶有利的非对称性和不对称性。虽然迟发性单侧耳聋已被报道改变这种模式，耳聋的一侧对中枢听觉可塑性的确切影响仍然不清楚。本研究旨在评估左侧和右侧耳聋是否对听觉区域的神经生理反应特征有不同的影响。18名单侧耳聋和16名听力正常的右利手受试者参加了研究。所有单侧耳聋的受试者都有语后聋。长潜伏期听觉诱发电位（late-AEPs）由两种类型的刺激，非语音（1 kHz的短纯音）和语音（无音节/pa/）提供给完整的耳朵在50 dB SL。早期外源成分的振幅和振幅（N100和P150）。左侧耳聋的受试者表现出主要的神经生理变化，在听觉区域上以更对称的激活模式的形式响应非-言语声音，甚至显著逆转的激活模式，有利于同侧皮层的刺激，以响应于言语声音。这不仅对AEP振幅而且对AEP时程都观察到。与此相反，没有显着的变化，报告为晚期AEP反应的主题与右侧deals.Conclusion：结果表明，单侧耳聋引起的皮层重组主要发生在左侧耳聋。这表明，解剖和功能的可塑性变化更可能发生在右侧而不是左侧听觉皮层。这种神经生理变化的可能的感知相关进行了讨论。
Background: In normal-hearing subjects, monaural stimulation produces a normal pattern of asynchrony and asymmetry over the auditory cortices in favour of the contralateral temporal lobe. While late onset unilateral deafness has been reported to change this pattern, the exact influence of the side of deafness on central auditory plasticity still remains unclear. The present study aimed at assessing whether left-sided and right-sided deafness had differential effects on the characteristics of neurophysiological responses over auditory areas. Eighteen unilaterally deaf and 16 normal hearing right-handed subjects participated. All unilaterally deaf subjects had post-lingual deafness. Long latency auditory evoked potentials (late-AEPs) were elicited by two types of stimuli, non-speech (1 kHz tone-burst) and speech-sounds (voiceless syllable/pa/) delivered to the intact ear at 50 dB SL. The latencies and amplitudes of the early exogenous components (N100 and P150) were measured using temporal scalp electrodes.Results: Subjects with left-sided deafness showed major neurophysiological changes, in the form of a more symmetrical activation pattern over auditory areas in response to non-speech sound and even a significant reversal of the activation pattern in favour of the cortex ipsilateral to the stimulation in response to speech sound. This was observed not only for AEP amplitudes but also for AEP time course. In contrast, no significant changes were reported for late-AEP responses in subjects with right-sided deafness.Conclusion: The results show that cortical reorganization induced by unilateral deafness mainly occurs in subjects with left-sided deafness. This suggests that anatomical and functional plastic changes are more likely to occur in the right than in the left auditory cortex. The possible perceptual correlates of such neurophysiological changes are discussed.